survivin Antibody (3F343): sc-73083
- survivin Antibody (3F343) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against full length human survivin
- recommended for detection of survivin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See survivin (D-8): sc-17779 for survivin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for survivin Antibody (3F343) for WB and IHC(P) applications. These reagents are now offered in bundles with survivin Antibody (3F343) (see ordering information below).
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Survivin Antibody (3F343) is a mouse monoclonal IgG1 antibody that detects survivin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Survivin plays a crucial role in regulating cell division and inhibiting apoptosis, making survivin a vital component in cancer biology, as survivin overexpression is often associated with tumor progression and resistance to chemotherapy. Survivin is primarily located in the cytoplasm and nucleus of dividing cells, where survivin associates with the mitotic spindle during cell division, ensuring proper chromosomal segregation. Survivin localization is significant because survivin not only contributes to the survival of cancer cells but also serves as a potential biomarker for cancer diagnosis and prognosis. Additionally, survivin interaction with microtubules is essential for survivin function, as survivin stabilizes the mitotic spindle, and any disruption in this interaction can lead to increased apoptosis and cell death. Anti-survivin antibody (3F343) is an invaluable tool for researchers studying the mechanisms of cancer cell survival and the potential therapeutic targets for cancer treatment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
survivin Antibody (3F343) References:
- Role of survivin and its splice variants in tumorigenesis. | Li, F. 2005. Br J Cancer. 92: 212-6. PMID: 15611788
- Survivin as a target for new anticancer interventions. | Zaffaroni, N., et al. 2005. J Cell Mol Med. 9: 360-72. PMID: 15963255
- microRNA-mediated survivin control of pluripotency. | Kapinas, K., et al. 2015. J Cell Physiol. 230: 63-70. PMID: 24891298
- The emerging role of exosomes in survivin secretion. | Khan, S., et al. 2015. Histol Histopathol. 30: 43-50. PMID: 25020159
- Survivin modulatory role in autoimmune and autoinflammatory diseases. | Pahlavan, Y., et al. 2019. J Cell Physiol. 234: 19440-19450. PMID: 31020660
- Survivin Promotes Piperlongumine Resistance in Ovarian Cancer. | Nan, XW., et al. 2019. Front Oncol. 9: 1345. PMID: 31850227
- Serum survivin is decreased in women with preeclampsia. | Güralp, O., et al. 2021. Hypertens Pregnancy. 40: 144-151. PMID: 34014801
- P53 and survivin expression in renal cell carcinoma. | Radovanović, M., et al. 2023. Urol Ann. 15: 186-190. PMID: 37304521
- microRNAs Regulate Survivin in Colorectal Cancer Patients. | Chavoshi, H., et al. 2023. Adv Biomed Res. 12: 227. PMID: 38073748
- Survivin promotes stem cell competence for skin cancer initiation. | Canato, S., et al. 2024. Cancer Discov.. PMID: 39526566
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
survivin Antibody (3F343) | sc-73083 | 200 µg/ml | $322.00 | |||
survivin Antibody (3F343): m-IgG Fc BP-HRP Bundle | sc-539448 | 200 µg Ab; 10 µg BP | $361.00 | |||
survivin Antibody (3F343): m-IgG1 BP-HRP Bundle | sc-541495 | 200 µg Ab; 20 µg BP | $361.00 |