survivin Antibody (3C5B2): sc-101432
- survivin Antibody (3C5B2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against recombinant full length survivin of human origin
- recommended for detection of survivin of human origin by ELISA
- See survivin (D-8): sc-17779 for survivin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for survivin Antibody (3C5B2). These reagents are now offered in bundles with survivin Antibody (3C5B2) (see ordering information below).
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Survivin Antibody (3C5B2) is a mouse monoclonal IgG1 antibody that detects survivin in human samples through enzyme-linked immunosorbent assay (ELISA). Survivin is a member of the inhibitor of apoptosis protein (IAP) family and plays a crucial role in regulating cell division and inhibiting apoptosis, making survivin a significant factor in cancer biology. Anti-survivin antibody (3C5B2) targets a protein predominantly located in the cytoplasm that associates with microtubules during the G2/M phase of the cell cycle, which is essential for proper mitotic spindle function. Survivin′s interaction with microtubules helps maintain spindle integrity and prevents activation of caspases, key mediators of apoptosis. Disruption of survivin′s association with microtubules can lead to increased caspase-3 activity, resulting in enhanced apoptosis and potential cell death, particularly relevant in cancer therapies aimed at inducing apoptosis in tumor cells. Survivin (3C5B2) antibody serves as an invaluable tool for researchers studying cell cycle regulation and apoptosis, as well as exploring therapeutic potential in cancer treatment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
survivin Antibody (3C5B2) References:
- Survivin inhibits apoptosis in cytotrophoblasts. | Shiozaki, A., et al. 2003. Placenta. 24: 65-76. PMID: 12495661
- HLA-A24 and survivin: possibilities in therapeutic vaccination against cancer. | Andersen, MH., et al. 2006. J Transl Med. 4: 38. PMID: 16948867
- Survivin in ovary tumors. | Plewka, D., et al. 2015. Ginekol Pol. 86: 525-30. PMID: 26376531
- Exploring the role of survivin in neuroendocrine neoplasms. | Hanif, A., et al. 2020. Oncotarget. 11: 2246-2258. PMID: 32577168
- Survivin modulation in the antimelanoma activity of prodiginines. | Branco, PC., et al. 2020. Eur J Pharmacol. 888: 173465. PMID: 32814079
- Survivin and caspases serum protein levels and survivin variants mRNA expression in sepsis. | Miliaraki, M., et al. 2021. Sci Rep. 11: 1049. PMID: 33441606
- Mutant p53 regulates Survivin to foster lung metastasis. | Tang, Q., et al. 2021. Genes Dev. 35: 528-541. PMID: 33737385
- Regulation of survivin protein stability by USP35 is evolutionarily conserved. | Wang, W., et al. 2021. Biochem Biophys Res Commun. 574: 48-55. PMID: 34438346
- A novel binding-induced DNAzyme motor triggered by survivin mRNA. | Liu, C., et al. 2022. Anal Bioanal Chem. 414: 6167-6175. PMID: 35767031
- Synovial fluid survivin and NETs as independent biomarkers in rheumatoid arthritis. | de Souza, FFL., et al. 2023. Clin Exp Rheumatol. 41: 1473-1479. PMID: 36441653
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
survivin Antibody (3C5B2) | sc-101432 | 200 µg/ml | $322.00 | |||
survivin Antibody (3C5B2): m-IgG Fc BP-HRP Bundle | sc-553209 | 200 µg Ab; 10 µg BP | $361.00 | |||
survivin Antibody (3C5B2): m-IgGκ BP-HRP Bundle | sc-553208 | 200 µg Ab; 40 µg BP | $361.00 | |||
survivin Antibody (3C5B2): m-IgG1 BP-HRP Bundle | sc-553210 | 200 µg Ab; 20 µg BP | $361.00 |