survivin Antibody (2H5H2): sc-101433
- survivin Antibody (2H5H2) is a mouse monoclonal IgG1 κ, cited in 10 publications, provided at 200 µg/ml
- raised against full length survivin of human origin
- recommended for detection of survivin of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for survivin Antibody (2H5H2). This work is in progress.
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Survivin Antibody (2H5H2) is a mouse monoclonal IgG1 antibody that detects survivin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Survivin plays a crucial role in regulating cell division and inhibiting apoptosis, making survivin a significant factor in cancer biology, as survivin overexpression is often associated with tumor progression and resistance to chemotherapy. Survivin is primarily located in the cytoplasm and nucleus of dividing cells, where survivin interacts with components of the mitotic spindle, thereby ensuring proper chromosome segregation during cell division. Survivin presence in these cellular compartments is vital for maintaining the balance between cell proliferation and programmed cell death, which is essential for normal tissue homeostasis. Additionally, survivin expression is tightly regulated throughout the cell cycle, with peak levels observed during the G2/M phase, highlighting survivin′s importance in cell cycle progression. Anti-survivin antibody (2H5H2) is an invaluable tool for researchers studying the mechanisms of cancer and apoptosis, providing insights into potential therapeutic targets for cancer treatment.
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survivin Antibody (2H5H2) References:
- Survivin promoter polymorphism and cervical carcinogenesis. | Borbély, AA., et al. 2007. J Clin Pathol. 60: 303-6. PMID: 16714396
- Targeting survivin in cancer therapy: fulfilled promises and open questions. | Pennati, M., et al. 2007. Carcinogenesis. 28: 1133-9. PMID: 17341657
- New wirings in the survivin networks. | Altieri, DC. 2008. Oncogene. 27: 6276-84. PMID: 18931693
- Survivin expression in renal cell carcinoma. | Zamparese, R., et al. 2008. Cancer Invest. 26: 929-35. PMID: 19034775
- The role of survivin for radiation oncology: moving beyond apoptosis inhibition. | Rödel, F., et al. 2011. Curr Med Chem. 18: 191-9. PMID: 21110807
- Survivin status affects prognosis and chemosensitivity in epithelial ovarian cancer. | Chen, L., et al. 2013. Int J Gynecol Cancer. 23: 256-63. PMID: 23358177
- Mitotic activity of survivin is regulated by acetylation at K129. | Aljaberi, AM., et al. 2015. Cell Cycle. 14: 1738-47. PMID: 25928399
- Survivin protects fused cancer cells from cell death. | Do, M., et al. 2017. BMB Rep. 50: 361-366. PMID: 28193315
- Survivin in breast lesions: immunohistochemical analysis of 196 cases. | Adamkov, M., et al. 2017. Pol J Pathol. 68: 297-305. PMID: 29517199
- Restoring apoptosis dysregulation using survivin inhibitor in nasopharyngeal cancer. | Shi, J., et al. 2020. Head Neck. 42: 913-923. PMID: 31925995
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
survivin Antibody (2H5H2) | sc-101433 | 200 µg/ml | $322.00 |