Sos 1 Antibody (E-11): sc-55528
- Sos 1 Antibody (E-11) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1057-1178 mapping near the C-terminus of Sos 1 of human origin
- recommended for detection of Sos 1 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Sos 1 Antibody (E-11) for WB applications. These reagents are now offered in bundles with Sos 1 Antibody (E-11) (see ordering information below).
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Sos 1 Antibody (E-11) is a mouse monoclonal IgG2a antibody that detects Sos 1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sos 1 plays a crucial role as a guanine nucleotide exchange factor (GEF) that activates Ras proteins, which are pivotal in regulating various cellular processes, including growth, differentiation, and survival. The activation of Ras by Sos 1 is essential for the transmission of signals from cell surface receptors to downstream effectors, thereby influencing critical pathways such as the MAP kinase signaling cascade. This interaction is particularly important in the context of cellular responses to growth factors and oncogenic signals, making Sos 1 a significant player in both normal physiology and cancer biology. By facilitating the exchange of GDP for GTP on Ras, Sos 1 not only initiates Ras signaling but also contributes to the fine-tuning of cellular responses to external stimuli. Sos 1 (E-11) antibody is an invaluable tool for researchers investigating the dynamics of Ras signaling and its implications in various diseases, including cancer.
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Sos 1 Antibody (E-11) References:
- Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals. | Chang, C., et al. 2000. EMBO J. 19: 3283-94. PMID: 10880441
- Mechanisms through which Sos-1 coordinates the activation of Ras and Rac. | Innocenti, M., et al. 2002. J Cell Biol. 156: 125-36. PMID: 11777939
- Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1. | Innocenti, M., et al. 2003. J Cell Biol. 160: 17-23. PMID: 12515821
- Growth inhibition of human pancreatic cancer cells by human interferon-beta gene combined with gemcitabine. | Endou, M., et al. 2005. Int J Mol Med. 15: 277-83. PMID: 15647844
- Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation. | Proepper, C., et al. 2007. EMBO J. 26: 1397-409. PMID: 17304222
- An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development. | Modzelewska, K., et al. 2007. Mol Cell Biol. 27: 3695-707. PMID: 17339331
- Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration. | Guittard, G., et al. 2015. Eur J Immunol. 45: 2389-95. PMID: 25973715
- Analysis of mutations in the SOS-1 gene in two Polish families with hereditary gingival fibromatosis. | Gawron, K., et al. 2017. Oral Dis. 23: 983-989. PMID: 28425619
- Combining SOS1 and MEK Inhibitors in a Murine Model of Plexiform Neurofibroma Results in Tumor Shrinkage. | Jackson, M., et al. 2023. J Pharmacol Exp Ther. 385: 106-116. PMID: 36849412
- Biochemical mechanisms of insulin resistance. | Roth, RA., et al. 1994. Horm Res. 41 Suppl 2: 51-5. PMID: 8088704
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sos 1 Antibody (E-11) | sc-55528 | 200 µg/ml | $322.00 | |||
Sos 1 Antibody (E-11): m-IgG Fc BP-HRP Bundle | sc-537063 | 200 µg Ab; 10 µg BP | $361.00 | |||
Sos 1 Antibody (E-11): m-IgGκ BP-HRP Bundle | sc-534249 | 200 µg Ab; 40 µg BP | $361.00 |