PP2A-Aα/β Antibody (4C10): sc-81604
- PP2A-Aα/β Antibody (4C10) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against His-tagged recombinant peptide corresponding to amino acids 1-168 of PP2A-Aα of human origin
- recommended for detection of PP2A-Aα and PP2A-Aβ of mouse, rat and human origin by WB and IP; may cross-react with PP2A-Aα of mouse origin
- See PP2A-Aα (6G3): sc-56954 for PP2A-Aα/β antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PP2A-Aα/β Antibody (4C10) for WB applications. These reagents are now offered in bundles with PP2A-Aα/β Antibody (4C10) (see ordering information below).
QUICK LINKS
SEE ALSO...
PP2A-Aα/β Antibody (4C10) is a mouse monoclonal IgG1 antibody that detects PP2A-Aα/β in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. PP2A-Aα/β is a crucial regulatory subunit of the protein phosphatase 2A (PP2A) complex, which plays a vital role in cellular signaling by dephosphorylating serine and threonine residues on target proteins. This dephosphorylation is essential for regulating various cellular processes, including cell division, apoptosis, and maintaining cellular homeostasis. The PP2A complex is composed of a catalytic subunit and regulatory subunits, with PP2A-Aα and PP2A-Aβ being key members that modulate the activity and specificity of the phosphatase. The interaction of PP2A-Aα/β with different regulatory subunits allows for the formation of diverse holoenzymes, which can target specific substrates and pathways, thereby influencing critical cellular functions. Understanding the dynamics of PP2A-Aα/β and its interactions is important for elucidating its role in various diseases, including cancer, where dysregulation of phosphatase activity can lead to aberrant signaling and uncontrolled cell growth.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PP2A-Aα/β Antibody (4C10) References:
- From the Biology of PP2A to the PADs for Therapy of Hematologic Malignancies. | Ciccone, M., et al. 2015. Front Oncol. 5: 21. PMID: 25763353
- Mastl/PP2A regulate Cdk1 in ooycte maturation. | Adhikari, D., et al. 2015. Oncotarget. 6: 18734-5. PMID: 26299916
- Protein Phosphatase 2A (PP2A) mutations in brain function, development, and neurologic disease. | Verbinnen, I., et al. 2021. Biochem Soc Trans. 49: 1567-1588. PMID: 34241636
- PP2A Phosphatase as an Emerging Viral Host Factor. | Barski, MS., et al. 2021. Front Cell Infect Microbiol. 11: 725615. PMID: 34422684
- Biased holoenzyme assembly of protein phosphatase 2A (PP2A): From cancer to small molecules. | Haanen, TJ., et al. 2022. J Biol Chem. 298: 102656. PMID: 36328247
- Pleiotropy of PP2A Phosphatases in Cancer with a Focus on Glioblastoma IDH Wildtype. | Kashani, E. and Vassella, E. 2022. Cancers (Basel). 14: PMID: 36358647
- CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation. | Qiu, M., et al. 2023. Sci Adv. 9: eadf8698. PMID: 37205756
- PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation. | Iannotta, L., et al. 2023. Front Mol Neurosci. 16: 1269387. PMID: 38169846
- Altering phosphorylation in cancer through PP2A modifiers. | Johnson, H., et al. 2024. Cancer Cell Int. 24: 11. PMID: 38184584
- Substrate recognition principles for the PP2A-B55 protein phosphatase. | Kruse, T., et al. 2024. Sci Adv. 10: eadp5491. PMID: 39356758
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PP2A-Aα/β Antibody (4C10) | sc-81604 | 200 µg/ml | $322.00 | |||
PP2A-Aα/β Antibody (4C10): m-IgG Fc BP-HRP Bundle | sc-539643 | 200 µg Ab; 10 µg BP | $361.00 | |||
PP2A-Aα/β Antibody (4C10): m-IgG1 BP-HRP Bundle | sc-541626 | 200 µg Ab; 20 µg BP | $361.00 |