Perphenazine CAS: 58-39-9
MF: C21H26ClN3OS
MW: 403.97
Perphenazine is a D2DR inhibitor.

Perphenazine (CAS 58-39-9)

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Aplicação Perphenazine is a D2DR inhibitor
Numero VAT: 58-39-9
Privada: ≥99%
Peso Molecular: 403.97
Separar por Funcao: C21H26ClN3OS
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).
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Perphenazine is a D2DR inhibitor which inhibits the glutamate dehydrogenase in vitro. Perphenazine also acts as a α-adrenergic receptor antagonist and σ-receptor agonist. Studies indicate that uncharged Perphenazine is better at forming complexes with cyclodextrins. In addition, Perphenazine forms more stable complexes with cyclodextrins than fluphenazine (sc-205700). Studies show that Perphenazine enhances the expression of CD71 on K562 cells, while at the same time inhibiting the proliferation of these cells.


Referencias

1. Lutka, A. and Prange, W. 2005. Acta Pol Pharm. 62(6): 419-425. PMID: 16583980

2. Yuan, L.B. and He, Q. 2005. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 30(3): 288-291. PMID: 16045015

Estado físico :
Solid
envie :
Soluble in ethanol (50 mg/ml), water (0.028 mg/ml at 24° C), methanol, and chloroform.
Manutencao :
Store at 4° C
Ponto de fusão :
97° C (lit.)
Ponto de fervura :
580.4° C at 760 mmHg
Densidade :
~1.3 g/cm3 (Predicted)
Indice de produtos :
n20D 1.63 (Predicted)
IC50 :
AOX1: IC50 = 33 nM (human); Aldehyde oxidase: IC50 = 740 nM (rat); Pleiotropic ABC efflux transporter of multiple drugs: IC50 = 1.4 µM (Saccharomyces cerevisiae S288c); Plasmodium falciparum: IC50 = 2.51 µM; HERG: IC50 = 4.22 µM (human)
Data ki :
SR-7: Ki= 23 nM (human); HERG: Ki= 3.45 µM (human)
Valores de pK :
pKa: 7.39, pKb: 7.94 (Predicted)
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
PubChem CID :
Indice de produtos :
14: 7183
Numero de FAX :
MFCD00056798
Numero de FAX :
200-381-5
SMILES :
C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO

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