Molecular structure of Pentostatin, CAS Number: 53910-25-1
Pentostatin (CAS 53910-25-1)
See product citations (5)
Alternate Names:
Deoxycoformycin; (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
Application:
Pentostatin is an adenosine deaminase inhibitor effective against cancer cell lines
CAS Number:
53910-25-1
Purity:
≥99%
Molecular Weight:
268.27
Molecular Formula:
C11H16N4O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pentostatin functions as a potent adenosine deaminase inhibitor, a key enzyme in purine metabolism. By binding to the active site of Pentostatin, the enzyme′s catalytic activity is hindered. Consequently, adenosine builds up due to this inhibition, providing an abundant substrate for other purine metabolism enzymes to utilize..
Pentostatin (CAS 53910-25-1) References
- Pentostatin: impact on outcome in hairy cell leukemia. | Grever, MR. 2006. Hematol Oncol Clin North Am. 20: 1099-108. PMID: 16990110
- Therapeutic benefit of pentostatin in severe IL-10-/- colitis. | Brown, JB., et al. 2008. Inflamm Bowel Dis. 14: 880-7. PMID: 18340641
- Pentostatin plus cyclophosphamide safely and effectively prevents immunotoxin immunogenicity in murine hosts. | Mossoba, ME., et al. 2011. Clin Cancer Res. 17: 3697-705. PMID: 21521777
- Fungal Cordycepin Biosynthesis Is Coupled with the Production of the Safeguard Molecule Pentostatin. | Xia, Y., et al. 2017. Cell Chem Biol. 24: 1479-1489.e4. PMID: 29056419
- FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA. | Carter, JM., et al. 2019. Nucleic Acids Res. 47: e113. PMID: 31361898
- Functional characterization of the human tRNA methyltransferases TRMT10A and TRMT10B. | Vilardo, E., et al. 2020. Nucleic Acids Res. 48: 6157-6169. PMID: 32392304
- Pentostatin antagonizes the antiviral activity of MBX-2168 by inhibiting the biosynthesis of the active compound. | Hagen, NR., et al. 2021. Antiviral Res. 187: 105018. PMID: 33476709
- Epitranscriptomics modifier pentostatin indirectly triggers Toll-like receptor 3 and can enhance immune infiltration in tumors. | Tusup, M., et al. 2022. Mol Ther. 30: 1163-1170. PMID: 34563676
- TLR8 is activated by 5'-methylthioinosine, a Plasmodium falciparum-derived intermediate of the purine salvage pathway. | Köllisch, G., et al. 2022. Cell Rep. 39: 110691. PMID: 35417716
- Mammalian N1-adenosine PARylation is a reversible DNA modification. | Musheev, MU., et al. 2022. Nat Commun. 13: 6138. PMID: 36253381
- Pentostatin-augmented interstitial adenosine prevents postcardioplegia injury in damaged hearts. | Hudspeth, DA., et al. 1994. Ann Thorac Surg. 58: 719-27. PMID: 7944694
- The in vitro cytotoxic effect of mitoxantrone in combination with fludarabine or pentostatin in B-cell chronic lymphocytic leukemia. | Morabito, F., et al. 1997. Haematologica. 82: 560-5. PMID: 9407721
- Comparative effects of cladribine, fludarabine and pentostatin on nucleotide metabolism in T- and B-cell lines. | Wilson, PK., et al. 1998. Int J Biochem Cell Biol. 30: 833-42. PMID: 9722988
Inhibitor of:
Ada2, Adad2, ADAR3, Adenosine deaminase, APRT, dCK, DERA, GART, Hairy Cell Leukemia Marker, HPRT, Ig λ, NASP, PNP, PRIM1, RNase 2, SAHH-3, SLC29 (solute carrier family 29), Trav12n-1, and XTP3TPA.Activator of:
Adad2, ADE2, ADO, CDD, ITPase, NT5C2, NUDT15, and PD-ECGF.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pentostatin, 10 mg | sc-204177 | 10 mg | $175.00 | |||
Pentostatin, 50 mg | sc-204177A | 50 mg | $702.00 |