p38 alpha MAPK14 Antibody (27): sc-136210

p38 alpha MAPK14 Antibody (27) is a mouse monoclonal IgG1 antibody engineered to recognize p38 alpha MAPK14, also known as p38α, MAP kinase 14, or CSBP, across mouse, rat, human, and canine species. p38 alpha MAPK14 monoclonal antibody (27) is raised against amino acids 243-355 of human p38 alpha MAPK14, making anti-p38 alpha MAPK14 antibody (27) suitable for applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). p38 alpha MAPK14 is a vital member of the mitogen-activated protein kinase (MAPK) family, characterized by a single protein kinase domain essential for phosphorylating various target proteins. Structurally, p38 alpha MAPK14 relies on magnesium ions as cofactors to facilitate ATP-dependent phosphorylation, a process critical for activating the kinase through phosphate group addition to threonine and tyrosine residues. This post-translational modification is crucial for regulating numerous cellular processes, including signal transduction, cytokine production, cell proliferation, differentiation, and apoptosis. p38 alpha MAPK14 interacts with several key proteins such as MKK3/6, ATF2, and MK2, which are integral to transmitting stress and inflammatory signals within the cell. Understanding these interactions and structural dynamics of p38 alpha MAPK14 helps researchers elucidate involvement in various signaling pathways and impact on cellular responses to external stimuli. Anti-p38 alpha MAPK14 antibody (27) enables scientists to investigate functional mechanisms and regulatory networks of this kinase, advancing studies in inflammation, cancer, and neurodegenerative diseases.

The preferred p38 alpha/beta MAPK antibody is p38 alpha/beta MAPK Antibody (A-12): sc-7972.