p-PKC delta Antibody (A-8): sc-377560

p-PKC δ Antibody (A-8) is a mouse monoclonal IgM antibody that detects p-PKC δ, specifically the Tyr 311 phosphorylated form, in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). p-PKC δ Antibody (A-8) is offered in a non-conjugated format, allowing for versatile experimental design. The protein kinase C (PKC) family, to which p-PKC δ belongs, is integral to numerous cellular processes, including cell growth, differentiation, and apoptosis, making p-PKC δ a critical target for understanding various signaling pathways. p-PKC δ is primarily located in the cytoplasm and can translocate to the membrane upon activation, which is essential for mediating cellular responses to growth factors and hormones. This translocation enables p-PKC δ to interact with other signaling molecules at the membrane, thereby influencing downstream signaling cascades that regulate vital cellular functions. p-PKC δ tyrosine phosphorylation further enhances regulatory capacity, as this modification can alter activity and interactions with other proteins, underscoring p-PKC δ importance in cellular signaling networks.

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p-PKC delta Antibody (A-8) References:

1. Vascular endothelial growth factor induces protein kinase C (PKC)-dependent Akt/PKB activation and phosphatidylinositol 3'-kinase-mediates PKC delta phosphorylation: role of PKC in angiogenesis.  |  Gliki, G., et al. 2002. Cell Biol Int. 26: 751-9. PMID: 12377207
2. Cross-regulation of novel protein kinase C (PKC) isoform function in cardiomyocytes. Role of PKC epsilon in activation loop phosphorylations and PKC delta in hydrophobic motif phosphorylations.  |  Rybin, VO., et al. 2003. J Biol Chem. 278: 14555-64. PMID: 12566450
3. Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells.  |  Nabha, SM., et al. 2005. Oncogene. 24: 3166-76. PMID: 15735693
4. Protein kinase C group B members PKC-delta, -epsilon, -zeta and PKC-L(eta). Comparison of properties of recombinant proteins in vitro and in vivo.  |  Liyanage, M., et al. 1992. Biochem J. 283 (Pt 3): 781-7. PMID: 1590767
5. Protein kinase C (PKC)-delta/-epsilon mediate the PKC/Akt-dependent phosphorylation of extracellular signal-regulated kinases 1 and 2 in MCF-7 cells stimulated by bradykinin.  |  Greco, S., et al. 2006. J Endocrinol. 188: 79-89. PMID: 16394177
6. Effect of hypoxia and aging on PKC delta-mediated sc-35 phosphorylation in rat myocardial tissue.  |  Cataldi, A., et al. 2009. Anat Rec (Hoboken). 292: 1135-42. PMID: 19645017
7. PKC-delta inhibitors sustain self-renewal of mouse embryonic stem cells under hypoxia in vitro.  |  Lee, HJ., et al. 2010. Exp Mol Med. 42: 294-301. PMID: 20177147
8. PKC-δ mediates interferon-α-induced apoptosis through c-Jun NH₂-terminal kinase activation.  |  Yanase, N., et al. 2012. BMC Cell Biol. 13: 7. PMID: 22435755
9. PKC-δ Promotes IL-1β-Induced Apoptosis of Rat Chondrocytes and Via Activating JNK and P38 MAPK Pathways.  |  Lu, J., et al. 2024. Cartilage. 15: 315-327. PMID: 37491820
10. Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells.  |  Szallasi, Z., et al. 1995. Biochem Biophys Res Commun. 214: 888-94. PMID: 7575560

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-PKC delta Antibody (A-8) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-p-PKC delta Antibody (A-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-PKC delta Antibody (A-8) Specifications

Alternate Product Name: PRKCD

Product Clone Name: A-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: Tyr 311

Epitope Target: PKC δ

Epitope Species: human

Product Reactivity/Detection: Tyr 311 phosphorylated PKC δ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for p-PKC delta Antibody (A-8): P: Blocking Peptide

The preferred PKC delta antibody is PKC delta Antibody (G-9): sc-8402.