O-Ac GD3 Antibody (7H2): sc-56170
- O-Ac GD3 Antibody (7H2) is a mouse monoclonal IgG1 κ O-Ac GD3 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against O-Ac GD3 of human origin
- O-Ac GD3 Antibody (7H2) is recommended for detection of O-Ac GD3 of human origin by IF
- Anti-O-Ac GD3 Antibody (7H2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for O-Ac GD3 Antibody (7H2). These reagents are now offered in bundles with O-Ac GD3 Antibody (7H2) (see ordering information below).
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O-Ac GD3 Antibody (7H2) is a mouse monoclonal IgG1 kappa light chain antibody that detects the O-Ac GD3 protein of human origin by immunofluorescence (IF). Anti-O-Ac GD3 antibody (7H2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. O-Ac GD3, also known as O-acetylated GD3 ganglioside, plays a crucial role in cell adhesion and the growth of malignant cells, making O-Ac GD3 significant in cancer research. O-Ac GD3 is primarily located on the cell surface of certain neural, neural crest, and renal cells, where O-Ac GD3 contributes to cellular interactions and signaling pathways. O-Ac GD3 on the cell surface is important for mediating cell-to-cell communication and may influence tumor progression and metastasis. Additionally, GD3 Synthase, the enzyme responsible for the synthesis of GD3, is localized in the Golgi apparatus and is a member of the glycosyltransferase family 29, highlighting GD3 Synthase′s essential role in the biosynthesis of gangliosides. O-Ac GD3 monoclonal antibody (7H2) is an invaluable tool for researchers investigating the functional implications of gangliosides in cellular processes and disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
O-Ac GD3 Antibody (7H2) References:
- Sequential immunization of melanoma patients with GD3 ganglioside vaccine and anti-idiotypic monoclonal antibody that mimics GD3 ganglioside. | Chapman, PB., et al. 2004. Clin Cancer Res. 10: 4717-23. PMID: 15269144
- Involvement of gangliosides in proliferation of immortalized neural progenitor cells. | Yanagisawa, M., et al. 2004. J Neurochem. 91: 804-12. PMID: 15525334
- The activity of GD3 synthase modulates the ganglioside pattern in rat liver. | Schüz-Henninger, R., et al. 1989. Eur J Biochem. 185: 327-30. PMID: 2583186
- O-acetyl GD3 ganglioside in human peripheral blood T lymphocytes. | Reivinen, J., et al. 1994. Int Immunol. 6: 1409-16. PMID: 7819150
- Shedding of GD2 ganglioside in patients with retinoblastoma. | Portoukalian, J., et al. 1993. Int J Cancer. 53: 948-51. PMID: 8473052
- Kinetic and spatial interrelationships between ganglioside glycosyltransferases and O-acetyltransferase(s) in human melanoma cells. | Sjoberg, ER. and Varki, A. 1993. J Biol Chem. 268: 10185-96. PMID: 8486686
- Variable region gene segments of nine monoclonal antibodies specific to disialogangliosides (GD2, GD3) and their O-acetylated derivatives. | Cerato, E., et al. 1997. Hybridoma. 16: 307-16. PMID: 9309421
- Permanent alteration of endogenous gangliosides in neuroblastoma cells by stable transfection with antisense vector. | Zeng, G., et al. 1998. Ann N Y Acad Sci. 845: 431. PMID: 9668392
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
O-Ac GD3 Antibody (7H2) | sc-56170 | 200 µg/ml | $322.00 | |||
O-Ac GD3 Antibody (7H2): m-IgG Fc BP-HRP Bundle | sc-528613 | 200 µg Ab; 10 µg BP | $361.00 | |||
O-Ac GD3 Antibody (7H2): m-IgGκ BP-HRP Bundle | sc-521033 | 200 µg Ab, 40 µg BP | $361.00 | |||
O-Ac GD3 Antibody (7H2): m-IgG1 BP-HRP Bundle | sc-543028 | 200 µg Ab; 20 µg BP | $361.00 | |||
O-Ac GD3 Antibody (7H2) AC | sc-56170 AC | 500 µg/ml, 25% agarose | $424.00 | |||
O-Ac GD3 Antibody (7H2) HRP | sc-56170 HRP | 200 µg/ml | $322.00 | |||
O-Ac GD3 Antibody (7H2) FITC | sc-56170 FITC | 200 µg/ml | $336.00 | |||
O-Ac GD3 Antibody (7H2) PE | sc-56170 PE | 200 µg/ml | $349.00 | |||
O-Ac GD3 Antibody (7H2) Alexa Fluor® 488 | sc-56170 AF488 | 200 µg/ml | $364.00 | |||
O-Ac GD3 Antibody (7H2) Alexa Fluor® 546 | sc-56170 AF546 | 200 µg/ml | $364.00 | |||
O-Ac GD3 Antibody (7H2) Alexa Fluor® 594 | sc-56170 AF594 | 200 µg/ml | $364.00 | |||
O-Ac GD3 Antibody (7H2) Alexa Fluor® 647 | sc-56170 AF647 | 200 µg/ml | $364.00 | |||
O-Ac GD3 Antibody (7H2) Alexa Fluor® 680 | sc-56170 AF680 | 200 µg/ml | $364.00 | |||
O-Ac GD3 Antibody (7H2) Alexa Fluor® 790 | sc-56170 AF790 | 200 µg/ml | $364.00 |