NGFR p75 Antibody (NGFR5): sc-58567

NGFR p75 Antibody (NGFR5) is a mouse monoclonal IgG1 antibody that detects NGFR p75 in human and feline samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). NGFR p75, also known as the low-affinity nerve growth factor receptor, plays a crucial role in the nervous system by modulating the effects of neurotrophic factors, particularly nerve growth factor (NGF). NGFR p75 is primarily located on the surface of neurons and glial cells, where NGFR p75 acts as a co-receptor that enhances the signaling of Trk receptors, such as Trk A. Anti-NGFR p75 antibody (NGFR5) is essential for studying efficient activation of Trk A, as NGFR p75 accelerates the receptor′s activation and facilitates the recruitment of downstream signaling molecules, thereby amplifying the neurotrophic response. This interaction is vital for neuronal survival, differentiation, and the maintenance of neuronal health, making NGFR p75 a significant player in neurobiology and a potential target for therapeutic interventions in neurodegenerative diseases. NGFR p75 monoclonal antibody (NGFR5) serves as an invaluable tool for researchers studying these critical pathways in both human and feline models.

The preferred NGFR p75 antibody is NGFR p75 Antibody (ME20.4): sc-13577.