MYH10 Antibody (F-11): sc-376989
- MYH10 Antibody (F-11) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-27 at the N-terminus of myosin heavy chain 10 of human origin
- recommended for detection of myosin heavy chain 10 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine and bovine
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MYH10 Antibody (F-11) for WB and IHC(P) applications. These reagents are now offered in bundles with MYH10 Antibody (F-11) (see ordering information below).
MYH10 Antibody (F-11) is a mouse monoclonal IgG2b antibody that detects MYH10 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MYH10, also known as Myosin IIb, Myosin-10, NMMHC-IIB, or nonmuscle myosin heavy chain IIb, plays a critical role in cellular dynamics, particularly in maintaining cell shape and facilitating cytokinesis. MYH10 is essential for various cellular movements, including phagocytosis and muscle contraction, by interacting with actin filaments to generate force. The presence of MYH10 in leukocytes and kidney glomeruli highlights its importance in specialized cellular functions, such as capping and secretion, which are vital for immune response and kidney function. Understanding MYH10′s role in these processes can provide insights into its involvement in various diseases, making anti-MYH10 antibody (F-11) a valuable tool for researchers studying cellular mechanics and pathology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MYH10 Antibody (F-11) References:
- Both Myosin-10 isoforms are required for radial neuronal migration in the developing cerebral cortex. | Ju, XD., et al. 2014. Cereb Cortex. 24: 1259-68. PMID: 23300110
- Myosin-10 produces its power-stroke in two phases and moves processively along a single actin filament under low load. | Takagi, Y., et al. 2014. Proc Natl Acad Sci U S A. 111: E1833-42. PMID: 24753602
- Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin Clouds. | Kwon, M., et al. 2015. Dev Cell. 34: 323-37. PMID: 26235048
- Myosin-10 independently influences mitotic spindle structure and mitotic progression. | Sandquist, JC., et al. 2016. Cytoskeleton (Hoboken). 73: 351-64. PMID: 27220038
- Competition between Coiled-Coil Structures and the Impact on Myosin-10 Bundle Selection. | Vavra, KC., et al. 2016. Biophys J. 110: 2517-2527. PMID: 27276269
- An interaction between myosin-10 and the cell cycle regulator Wee1 links spindle dynamics to mitotic progression in epithelia. | Sandquist, JC., et al. 2018. J Cell Biol. 217: 849-859. PMID: 29321170
- Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma. | Kenchappa, RS., et al. 2020. iScience. 23: 101802. PMID: 33299973
- Myosin 10 uses its MyTH4 and FERM domains differentially to support two aspects of spindle pole biology required for mitotic spindle bipolarity. | Yim, YI., et al. 2023. bioRxiv.. PMID: 37398378
- Vimentin-mediated myosin 10 aggregation at tips of cell extensions drives MT1-MMP-dependent collagen degradation in colorectal cancer. | Ostrowska-Podhorodecka, Z., et al. 2023. FASEB J. 37: e23097. PMID: 37440280
- Mechanisms underlying Myosin 10's contribution to the maintenance of mitotic spindle bipolarity. | Yim, YI., et al. 2024. Mol Biol Cell. 35: ar14. PMID: 38019611
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MYH10 Antibody (F-11) | sc-376989 | 200 µg/ml | $322.00 | |||
MYH10 Antibody (F-11): m-IgGκ BP-HRP Bundle | sc-535533 | 200 µg Ab; 40 µg BP | $361.00 | |||
MYH10 Antibody (F-11): m-IgG2b BP-HRP Bundle | sc-549446 | 200 µg Ab; 10 µg BP | $361.00 | |||
MYH10 (F-11) Neutralizing Peptide | sc-376989 P | 100 µg/0.5 ml | $69.00 |