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Methocarbamol (CAS 532-03-6)

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Alternate Names:
3-(2-Methoxyphenoxy)-1,2-propanediol 1-Carbamate; 3-(o-Methoxyphenoxy)-2-hydroxypropyl Carbamate; AHR 85
Application:
Methocarbamol is a skeletal muscle relaxant
CAS Number:
532-03-6
Molecular Weight:
241.24
Molecular Formula:
C11H15NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methocarbamol, a derivative of guaifenesin classified under the carbamate group, displays a distinct preference for binding with carbonic anhydrase (CA) enzymes, showcasing a notable selectivity for carbonic anhydrase I (CA I) compared to carbonic anhydrase II (CA II), with the disparity in binding affinities being remarkably vast. This specificity highlights its utility in scientific investigations aimed at understanding the enzymatic pathways and functional roles of CA isoenzymes. By inhibiting CA I and CA II, methocarbamol becomes a key tool in examining the enzyme′s contributions to a variety of biochemical functions, such as pH regulation and CO2 transport within tissues. This inhibitory action not only sheds light on how carbonic anhydrases play a role in maintaining cellular and overall physiological balance but also serves as a foundation for further research into modulating enzyme activity and deciphering metabolic processes critical for cellular respiration and ion movement.


Methocarbamol (CAS 532-03-6) References

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  2. Determination of methocarbamol concentration in human plasma by high performance liquid chromatography-tandem mass spectrometry.  |  Zha, W. and Zhu, Z. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 831-5. PMID: 20171150
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  8. Gamma irradiation-induced degradation and mineralization of methocarbamol in aqueous solution.  |  Zaouak, A., et al. 2022. Environ Technol. 1-8. PMID: 35200109
  9. The effect of methocarbamol and mexiletine on murine muscle spindle function.  |  Watkins, B., et al. 2022. Muscle Nerve. 66: 96-105. PMID: 35373353
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methocarbamol, 1 g

sc-211809
1 g
$205.00

Methocarbamol, 1 g

sc-211809-CW
1 g
$390.00