L-ficolin Antibody (FCN216): sc-130296

L-ficolin Antibody (FCN216) is a mouse monoclonal IgG1 antibody that detects L-ficolin in human samples through applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). L-ficolin, also known as ficolin-2 or ficolin-B in mouse and rat, is a 313 amino acid protein belonging to the ficolin lectin family, playing a crucial role in the innate immune response. Anti-L-ficolin antibody (FCN216) recognizes a protein primarily secreted by the liver and circulates in plasma, where L-ficolin forms a disulfide-linked homopolymer, which can lead to the formation of a functional dodecamer polypeptide. L-ficolin′s ability to bind to DNA ligands expressed by late apoptotic and necrotic cells is vital for enhancing the attachment and engulfment of these cells, thereby facilitating the clearance of cellular debris and maintaining tissue homeostasis. Notably, variations in L-ficolin concentrations among individuals have been linked to polymorphisms in the promoter and structural regions of the FCN2 gene, with significant implications for conditions such as Behçet′s disease, where allele frequency differences in single nucleotide polymorphisms within the FCN2 gene promoter have been observed between HLA-B51-positive and HLA-B51-negative subgroups. L-ficolin monoclonal antibody (FCN216) serves as an essential tool for researchers investigating L-ficolin′s role in immune responses and potential implications in various diseases.

The preferred L-ficolin antibody is L-ficolin Antibody (FCN219): sc-130297.