Molecular structure of KC 12291 hydrochloride, CAS Number: 181936-98-1
KC 12291 hydrochloride (CAS 181936-98-1)
Application:
KC 12291 hydrochloride is an atypical voltage-gated sodium channel blocker
CAS Number:
181936-98-1
Molecular Weight:
449.99
Molecular Formula:
C22H27N3O3S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro (IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo.
KC 12291 hydrochloride (CAS 181936-98-1) References
Decking et al (1998) Cardioprotective actions of KC 12291. Naunyn Schmiedebergs Arch.Pharmacol. 358 547. Tamareille et al (2002) Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels. J.Cardiovasc.Pharmacol. 40 346. John et al (2004) KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc.Drug Rev. 22 17. Letienne et al (2006) Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart. Eur.J.Pharmacol. 530 243.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KC 12291 hydrochloride, 10 mg | sc-204028 | 10 mg | $175.00 | |||
KC 12291 hydrochloride, 50 mg | sc-204028A | 50 mg | $739.00 |