ING1 Antibody (E-2): sc-374295

ING1 Antibody (E-2) is a mouse monoclonal IgG1 antibody that detects ING1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ING1, or Inhibitor of Growth Protein 1, is a crucial 422 amino acid protein encoded by the human gene ING1, belonging to the ING family and characterized by the presence of a PHD-type zinc finger. ING1 plays a significant role in regulating cell growth by cooperating with the tumor suppressor protein p53/TP53, thereby modulating p53-dependent transcriptional activation, which is vital for maintaining cellular homeostasis and preventing uncontrolled cell proliferation. ING1′s importance is underscored by classification as a tumor suppressor gene, with several isoforms, including p47ING1, p33ING1, and p24ING1, exhibiting varying expression patterns across different tissues. Notably, p33ING1 isoform is universally expressed in all normal tissues, while p24ING1 isoform is predominantly found in the testis, liver, and kidney, with limited expression in the colon and brain, but absent in breast tissue and cultured melanocytes. The diverse expression of these isoforms highlights the functional complexity of ING1 and potential implications in cancer biology, making anti-ING1 antibody (E-2) an essential tool for researchers investigating pathways of cell growth regulation and tumor suppression.

The preferred p33ING1 antibody is p33ING1 Antibody (CAb 3): sc-21728.