IFN-β Antibody (MIB-8C4.1): sc-53586
- IFN-β Antibody (MIB-8C4.1) is a Armenian hamster monoclonal IgG provided at 200 µg/ml
- raised against recombinant IFN of mouse origin
- IFN-beta Antibody (MIB-8C4.1) is recommended for detection of IFN-β of mouse origin by WB and IP
- Anti-IFN-beta Antibody (MIB-8C4.1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IFN-β Antibody (MIB-8C4.1). This work is in progress.
IFN-β Antibody (MIB-8C4.1) is a hamster monoclonal IgG antibody that detects mouse IFN-β by western blotting (WB) and immunoprecipitation (IP). IFN-β monoclonal antibody (MIB-8C4.1) is an Armenian hamster antibody raised against recombinant mouse IFN-β. IFN-β (MIB-8C4.1) antibody is available in non-conjugated form and conjugated to agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® dyes. IFN-β plays a crucial role in immune response, particularly in regulating antiviral activity, making IFN-β essential for defense against viral infections. Fibroblasts and leukocytes produce IFN-β in response to viral infections and other stimuli. IFN-β activates immune cells and enhances major histocompatibility complex (MHC) molecule expression, vital for recognizing and eliminating infected cells. IFN-β demonstrates antitumor properties and serves in clinical treatments for various malignancies, myelodysplastic syndromes, and autoimmune diseases. Located on human chromosome 9, IFN-β clusters with other type I interferon genes, highlighting IFN-β′s importance in immune regulation. Type I interferon receptor interacts with IFN-β through a multisubunit receptor, mediating diverse biological effects in both innate and adaptive immunity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IFN-β Antibody (MIB-8C4.1) References:
- IFN-beta in rheumatoid arthritis. | Tak, PP. 2004. Front Biosci. 9: 3242-7. PMID: 15353352
- IFN-β and multiple sclerosis: from etiology to therapy and back. | Annibali, V., et al. 2015. Cytokine Growth Factor Rev. 26: 221-8. PMID: 25466632
- Direct Antimicrobial Activity of IFN-β. | Kaplan, A., et al. 2017. J Immunol. 198: 4036-4045. PMID: 28411186
- IFN-β rescues neurodegeneration by regulating mitochondrial fission via STAT5, PGAM5, and Drp1. | Tresse, E., et al. 2021. EMBO J. 40: e106868. PMID: 33913175
- IFN-β mediates the anti-osteoclastic effect of bisphosphonates and dexamethasone. | Kalkar, P., et al. 2022. Front Pharmacol. 13: 1002550. PMID: 36386129
- Pim1 promotes IFN-β production by interacting with IRF3. | Ko, R., et al. 2022. Exp Mol Med. 54: 2092-2103. PMID: 36446848
- Coxsackievirus A6 2C protein antagonizes IFN-β production through MDA5 and RIG-I depletion. | Wang, S-H., et al. 2023. J Virol. 97: e0107523. PMID: 37847581
- Lactate-lactylation-HSPA6 axis promotes PRRSV replication by impairing IFN-β production. | Pang, Y., et al. 2024. J Virol. 98: e0167023. PMID: 38088561
- 15-Lipoxygenase promotes resolution of inflammation in lymphedema by controlling Treg cell function through IFN-β. | Zamora, A., et al. 2024. Nat Commun. 15: 221. PMID: 38177096
- Itaconate modulates mitochondria for antiviral IFN-β. | Cordes, T. and Hiller, K. 2024. Nat Metab. 6: 2027-2028. PMID: 39406968
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-β Antibody (MIB-8C4.1) | sc-53586 | 200 µg/ml | $322.00 | |||
IFN-β Antibody (MIB-8C4.1) AC | sc-53586 AC | 500 µg/ml, 25% agarose | $424.00 | |||
IFN-β Antibody (MIB-8C4.1) HRP | sc-53586 HRP | 200 µg/ml | $322.00 | |||
IFN-β Antibody (MIB-8C4.1) FITC | sc-53586 FITC | 200 µg/ml | $336.00 | |||
IFN-β Antibody (MIB-8C4.1) PE | sc-53586 PE | 200 µg/ml | $349.00 | |||
IFN-β Antibody (MIB-8C4.1) Alexa Fluor® 488 | sc-53586 AF488 | 200 µg/ml | $364.00 | |||
IFN-β Antibody (MIB-8C4.1) Alexa Fluor® 546 | sc-53586 AF546 | 200 µg/ml | $364.00 | |||
IFN-β Antibody (MIB-8C4.1) Alexa Fluor® 594 | sc-53586 AF594 | 200 µg/ml | $364.00 | |||
IFN-β Antibody (MIB-8C4.1) Alexa Fluor® 647 | sc-53586 AF647 | 200 µg/ml | $364.00 | |||
IFN-β Antibody (MIB-8C4.1) Alexa Fluor® 680 | sc-53586 AF680 | 200 µg/ml | $364.00 | |||
IFN-β Antibody (MIB-8C4.1) Alexa Fluor® 790 | sc-53586 AF790 | 200 µg/ml | $364.00 |