HIG2 Antibody (G-2): sc-376704

HIG2 Antibody (G-2) is a mouse monoclonal IgG3 kappa light chain antibody that detects HIG2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-HIG2 antibody (G-2) is available as the non-conjugated form. HIG2, also known as hypoxia-inducible gene 2 protein or C7orf68, plays a crucial role in cellular responses to hypoxia, particularly in cancer. HIG2 is a 63 amino acid single-pass membrane protein that is upregulated in response to low oxygen levels and glucose deprivation, helping cells adapt to adverse conditions. HIG2 expression is elevated in cervical cancer cells, while suppressed in renal cell carcinoma, indicating potential as a biomarker for tumor progression. HIG2 interacts with the extracellular domain of frizzled-10, enhancing oncogenic Wnt signaling and promoting its own transcription, suggesting action as an autocrine growth factor. HIG2 is encoded on human chromosome 7, a region associated with various genetic disorders, highlighting the importance of understanding function and regulation in both normal physiology and disease states. HIG2 may serve as a promising target for molecular-targeting therapies and could be a valuable diagnostic marker for patients with renal carcinomas.

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HIG2 Antibody (G-2) References:

1. Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment.  |  Denko, N., et al. 2000. Clin Cancer Res. 6: 480-7. PMID: 10690527
2. The DNA sequence of human chromosome 7.  |  Hillier, LW., et al. 2003. Nature. 424: 157-64. PMID: 12853948
3. Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy.  |  Togashi, A., et al. 2005. Cancer Res. 65: 4817-26. PMID: 15930302
4. ZD6474 inhibits tumor growth and intraperitoneal dissemination in a highly metastatic orthotopic gastric cancer model.  |  Arao, T., et al. 2006. Int J Cancer. 118: 483-9. PMID: 16052530
5. Gene profiling involved in immature CD4+ T lymphocyte responsible for systemic lupus erythematosus.  |  Deng, YJ., et al. 2006. Mol Immunol. 43: 1497-507. PMID: 16143398
6. Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells.  |  Bray, JD., et al. 2005. J Steroid Biochem Mol Biol. 97: 328-41. PMID: 16157482
7. The neurobiology of Williams syndrome: cascading influences of visual system impairment?  |  Eckert, MA., et al. 2006. Cell Mol Life Sci. 63: 1867-75. PMID: 16810457
8. Williams-Beuren syndrome diagnosis using fluorescence in situ hybridization.  |  Osborne, LR., et al. 2006. Methods Mol Med. 126: 113-28. PMID: 16930009
9. Structural aberrations of chromosome 7 revealed by a combination of molecular cytogenetic techniques in myeloid malignancies.  |  Brezinová, J., et al. 2007. Cancer Genet Cytogenet. 173: 10-6. PMID: 17284364
10. Therapy-related leukemia and myelodysplasia: susceptibility and incidence.  |  Leone, G., et al. 2007. Haematologica. 92: 1389-98. PMID: 17768113
11. Molecular anatomy of chromosome 7q deletions in myeloid neoplasms: evidence for multiple critical loci.  |  Liang, H., et al. 1998. Proc Natl Acad Sci U S A. 95: 3781-5. PMID: 9520444

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HIG2 Antibody (G-2) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-HIG2 Antibody (G-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HIG2 Antibody (G-2) Specifications

Alternate Product Name: HIG2

Product Clone Name: G-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 39-61

Epitope Target: HIG2

Epitope Species: human

Product Reactivity/Detection: HIG2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for HIG2 Antibody (G-2): P: Blocking Peptide