GHR Antibody (MAB 43): sc-69881

GHR Antibody (MAB 43) is a mouse monoclonal IgG1 antibody that detects growth hormone receptor (GHR) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). GHR is a crucial integral membrane protein that plays a significant role in mediating the effects of growth hormone (GH), which is essential for regulating body growth and various metabolic processes. The importance of GHR lies not only in its function as a receptor but also in its structural characteristics; GHR belongs to the cytokine receptor family, known for existing in both membrane-bound and soluble forms. The soluble form, known as GH-binding protein (GHBP), is produced through proteolytic cleavage of GHR′s extracellular domain and serves as a critical modulator of GH activity. Notably, reduced GHBP levels are linked to growth hormone insensitivity syndrome (GHIS), highlighting GHR′s clinical relevance in growth regulation. GHR is transcribed from at least two distinct promoters, resulting in two isoforms, GHR 1A and GHR 1B, with GHR 1A and 1B being expressed in the liver, while GHR 1B is additionally found in muscle, uterus, and ovary tissues, underscoring GHR′s diverse physiological roles. Anti-GHR antibody (MAB 43) serves as an invaluable tool for researchers investigating the complexities of growth hormone signaling and its implications in health and disease.

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GHR Antibody (MAB 43) References:

1. Growth hormone receptor (GHR) gene polymorphism and scoliosis in Prader-Willi syndrome.  |  Butler, MG., et al. 2018. Growth Horm IGF Res. 39: 29-33. PMID: 29273483
2. Growth hormone (GH) receptor (GHR)-specific inhibition of GH-Induced signaling by soluble IGF-1 receptor (sol IGF-1R).  |  Zhang, Y., et al. 2019. Mol Cell Endocrinol. 492: 110445. PMID: 31100495
3. Lysosomal targetomics of ghr KO mice shows chaperone-mediated autophagy degrades nucleocytosolic acetyl-coA enzymes.  |  Endicott, SJ., et al. 2022. Autophagy. 18: 1551-1571. PMID: 34704522
4. 22-kD growth hormone-induced nuclear GHR/STAT5/CyclinD1 signaling pathway plays an important role in promoting mesenchymal stem cell proliferation.  |  Zheng, WV., et al. 2022. Biofactors. 48: 67-85. PMID: 34866251
5. The nuclear-localized GHR is involved in the cell proliferation of gastric cancer, and pegvisomant may be an important potential drug to inhibit the proliferation of gastric cancer cells.  |  Meng, Y., et al. 2022. Biochem Cell Biol. 100: 125-135. PMID: 35061546
6. Resistance to mild cold stress is greater in both wild-type and long-lived GHR-KO female mice.  |  Fang, Y., et al. 2023. Geroscience. 45: 1081-1093. PMID: 36527583
7. Growth hormone receptor (GHR) in AgRP neurons regulates thermogenesis in a sex-specific manner.  |  Stilgenbauer, L., et al. 2023. Geroscience. 45: 1745-1759. PMID: 36633824
8. Deletion of hepatic growth hormone receptor (GHR) alters the mouse gut microbiota by affecting bile acid metabolism.  |  Yu, Z., et al. 2023. Gut Microbes. 15: 2221098. PMID: 37306416
9. The Exon 3-Deleted Growth Hormone Receptor (d3GHR) Polymorphism-A Favorable Backdoor Mechanism for the GHR Function.  |  Falah, G., et al. 2023. Int J Mol Sci. 24: PMID: 37762211
10. Role of the Growth Hormone Receptor (GHR) Gene in Skeletal Class II Malocclusion and Its Significant Influence on the Skeletal Facial Profile in Both the Sagittal and Vertical Dimensions: A Systematic Review.  |  George, AM., et al. 2024. Cureus. 16: e53596. PMID: 38449954

The preferred GHR antibody is GHR Antibody (B-10): sc-137185.