Filamin 1 Antibody (5): sc-135906
- Filamin 1 Antibody (5) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 2492-2647 of Filamin 1 of human origin
- recommended for detection of Filamin 1 of human origin by WB, IP and IF; not recommended for IP
- See Filamin 1 (E-3): sc-17749 for Filamin 1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Filamin 1 Antibody (5). This work is in progress.
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Filamin 1 Antibody (5) is a mouse monoclonal IgG1 antibody that detects Filamin 1 in human samples through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Filamin 1 is a crucial actin-binding protein that plays a significant role in maintaining the structural integrity of the cytoskeleton by crosslinking actin filaments into a three-dimensional network. This network is essential for various cellular processes, including maintaining cell shape, enabling cell motility, and facilitating intracellular transport. Anti-Filamin 1 antibody (5) helps researchers study cellular signaling pathways and mechanotransduction, where Filamin 1 helps cells respond to mechanical stimuli. Filamin 1 interacts with several other proteins, including integrins and various signaling molecules, which further underscores its role in cellular architecture and function. Filamin 1′s ability to form homodimers enhances its capacity to stabilize actin structures, making Filamin 1 a vital component in both muscle and non-muscle tissues. With diverse functions and interactions, Filamin 1 monoclonal antibody (5) provides a valuable tool for researchers studying these critical processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Filamin 1 Antibody (5) References:
- [Filamin A as a mediator of alterations in cancer cells]. | Wieczorek, K. and Niewiarowska, J. 2014. Postepy Biochem. 60: 77-83. PMID: 25033545
- Filamin A Is Involved in HIV-1 Vpu-mediated Evasion of Host Restriction by Modulating Tetherin Expression. | Dotson, D., et al. 2016. J Biol Chem. 291: 4236-46. PMID: 26742839
- Filamin A modulates platelet function. | Lopez, JJ., et al. 2018. Aging (Albany NY). 10: 3052-3053. PMID: 30401791
- FLN-1/filamin is required to anchor the actomyosin cytoskeleton and for global organization of sub-cellular organelles in a contractile tissue. | Kelley, CA., et al. 2020. Cytoskeleton (Hoboken). 77: 379-398. PMID: 32969593
- Filamin-A expression in laryngeal squamous cell carcinoma and its clinical significance. | Ouban, A. 2022. Histol Histopathol. 37: 125-136. PMID: 34677823
- Deficiency of filamin A in smooth muscle cells protects against hypoxia‑mediated pulmonary hypertension in mice. | Zheng, Y., et al. 2023. Int J Mol Med. 51: PMID: 36704846
- Filamin A is overexpressed in non-alcoholic steatohepatitis and contributes to the progression of inflammation and fibrosis. | Lu, Y., et al. 2023. Biochem Biophys Res Commun. 653: 93-101. PMID: 36863213
- Filamin-A-interacting protein 1 (FILIP1) is a dual compartment protein linking myofibrils and microtubules during myogenic differentiation and upon mechanical stress. | Grande, V., et al. 2023. Cell Tissue Res. 393: 133-147. PMID: 37178194
- Filamin A is involved in human intrahepatic cholangiocarcinoma aggressiveness and progression. | Vitali, E., et al. 2024. Liver Int. 44: 518-531. PMID: 38010911
- Filamin A in triple negative breast cancer. | Giovannelli, P., et al. 2024. Steroids. 205: 109380. PMID: 38311094
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Filamin 1 Antibody (5) | sc-135906 | 50 µg/0.5 ml | $322.00 |