Fibulin-2 Antibody (7H4F6): sc-130060
- Fibulin-2 Antibody (7H4F6) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 180-440 of Fibulin-2 of human origin
- recommended for detection of Fibulin-2 of human origin by WB, IP and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Fibulin-2 Antibody (7H4F6) for WB applications. These reagents are now offered in bundles with Fibulin-2 Antibody (7H4F6) (see ordering information below).
Fibulin-2 Antibody (7H4F6) is a mouse monoclonal IgG1 antibody that detects Fibulin-2 in human samples through applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Fibulin-2 plays a crucial role in the extracellular matrix, where Fibulin-2 is primarily located in basement membranes and connective tissue compartments, particularly in the heart, placenta, and ovarian tissue. This localization is significant as Fibulin-2 contributes to the structural integrity and function of these tissues, influencing processes such as cell adhesion, migration, and tissue repair. Additionally, Fibulin-2 interacts with other extracellular matrix proteins, including aggrecan, versican, and brevican, which are vital for maintaining the architecture of the extracellular matrix and facilitating cellular communication. The gene encoding human Fibulin-2 is mapped to chromosome 3p25.1, and Fibulin-2 expression is notably altered in various pathological conditions, including diabetic kidneys and glomerulosclerosis, highlighting Fibulin-2′s potential as a biomarker for disease progression. Anti-Fibulin-2 antibody (7H4F6) is an essential tool for researchers investigating the roles of extracellular matrix components in health and disease.
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Fibulin-2 Antibody (7H4F6) References:
- Fibulin-2 is a driver of malignant progression in lung adenocarcinoma. | Baird, BN., et al. 2013. PLoS One. 8: e67054. PMID: 23785517
- Fibulin-2 deficiency attenuates angiotensin II-induced cardiac hypertrophy by reducing transforming growth factor-β signalling. | Zhang, H., et al. 2014. Clin Sci (Lond). 126: 275-88. PMID: 23841699
- Fibulin-2 is essential for angiotensin II-induced myocardial fibrosis mediated by transforming growth factor (TGF)-β. | Khan, SA., et al. 2016. Lab Invest. 96: 773-83. PMID: 27111286
- Fibulin-2 inhibits development of gastric cancer by downregulating β-catenin. | Ma, H., et al. 2019. Oncol Lett. 18: 2799-2804. PMID: 31452758
- Expression of Fibulin-2 and Fibulin-5 on subretinal fluid in human primary rhegmatogenous retinal detachment. | Davila-Avila, N., et al. 2020. Exp Eye Res. 194: 107992. PMID: 32151522
- Correlation of Fibulin-2 expression with proliferation, migration and invasion of breast cancer cells. | Zhang, X., et al. 2020. Oncol Lett. 20: 1945-1951. PMID: 32724439
- Fibulin-2: A Novel Biomarker for Differentiating Grade II from Grade I Meningiomas. | Sofela, AA., et al. 2021. Int J Mol Sci. 22: PMID: 33429944
- Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer. | Klingen, TA., et al. 2021. PLoS One. 16: e0249767. PMID: 33836007
- Fibulin-2 Facilitates Malignant Progression of Hepatocellular Carcinoma. | Hu, X., et al. 2023. Turk J Gastroenterol. 34: 635-644. PMID: 37162505
- Fibulin-2 is an extracellular matrix inhibitor of oligodendrocytes relevant to multiple sclerosis. | Ghorbani, S., et al. 2024. J Clin Invest. 134: PMID: 38743490
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fibulin-2 Antibody (7H4F6) | sc-130060 | 200 µg/ml | $322.00 | |||
Fibulin-2 Antibody (7H4F6): m-IgG Fc BP-HRP Bundle | sc-539800 | 200 µg Ab; 10 µg BP | $361.00 | |||
Fibulin-2 Antibody (7H4F6): m-IgG1 BP-HRP Bundle | sc-541718 | 200 µg Ab; 20 µg BP | $361.00 |