dcTRAILR2 Antibody (6D350): sc-70957
- dcTRAILR2 Antibody (6D350) is a rat monoclonal IgG2a provided at 50 µg/0.5 ml
- raised against dcTRAILR2 corresponding to amino acids 1-170 of mouse origin
- recommended for detection of dcTRAILR2 of mouse origin by FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for dcTRAILR2 Antibody (6D350). This work is in progress.
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dcTRAILR2 Antibody (6D350) is a rat monoclonal IgG2a antibody that detects dcTRAILR2 in mouse samples through flow cytometry (FCM). dcTRAILR2, also known as decoy TRAIL receptor 2, plays a crucial role in regulating apoptosis by acting as a protective mechanism against the cytotoxic effects of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Unlike its counterparts, dcTRAILR2 lacks a cytoplasmic death domain, preventing initiation of apoptosis or activation of the NFκB pathway. Instead, dcTRAILR2 competes with functional TRAIL receptors for ligand binding, thereby inhibiting TRAIL-mediated apoptosis and providing a survival advantage to cells in the tumor microenvironment. This function is particularly important in cancer biology, as dcTRAILR2 allows tumor cells to evade programmed cell death, contributing to tumor progression and resistance to therapy. Anti-dcTRAILR2 antibody (6D350) serves as an essential tool for researchers studying the mechanisms of apoptosis and the role of TRAIL signaling in cancer, enabling the exploration of potential therapeutic strategies targeting this pathway.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
dcTRAILR2 Antibody (6D350) | sc-70957 | 50 µg/0.5 ml | $322.00 |