DcR3 Antibody (F-4): sc-365755

DcR3 Antibody (F-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects DcR3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DcR3 (F-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. DcR3 plays a critical role in modulating immune response by acting as a decoy receptor for tumor necrosis factor (TNF) ligands, particularly in the context of apoptosis. By binding to TNF-related ligands, DcR3 can inhibit the activation of pro-apoptotic signaling pathways, thereby contributing to cellular resistance against apoptosis. This function is particularly important in the tumor microenvironment, where DcR3 may help cancer cells evade immune surveillance and promote tumor growth. Understanding DcR3′s role in these processes can provide insights into potential therapeutic strategies targeting immune evasion in cancer.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

DcR3 Antibody (F-4) References:

1. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis.  |  Yu, KY., et al. 1999. J Biol Chem. 274: 13733-6. PMID: 10318773
2. DcR3 protects THP-1 macrophages from apoptosis by increasing integrin alpha4.  |  Tateishi, K., et al. 2009. Biochem Biophys Res Commun. 389: 593-8. PMID: 19748482
3. The Fas death factor.  |  Nagata, S. and Golstein, P. 1995. Science. 267: 1449-56. PMID: 7533326
4. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death.  |  Smith, CA., et al. 1994. Cell. 76: 959-62. PMID: 8137429
5. A novel domain within the 55 kd TNF receptor signals cell death.  |  Tartaglia, LA., et al. 1993. Cell. 74: 845-53. PMID: 8397073
6. A death-domain-containing receptor that mediates apoptosis.  |  Kitson, J., et al. 1996. Nature. 384: 372-5. PMID: 8934525
7. The receptor for the cytotoxic ligand TRAIL.  |  Pan, G., et al. 1997. Science. 276: 111-3. PMID: 9082980
8. An antagonist decoy receptor and a death domain-containing receptor for TRAIL.  |  Pan, G., et al. 1997. Science. 277: 815-8. PMID: 9242610
9. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.  |  Sheridan, JP., et al. 1997. Science. 277: 818-21. PMID: 9242611
10. A novel receptor for Apo2L/TRAIL contains a truncated death domain.  |  Marsters, SA., et al. 1997. Curr Biol. 7: 1003-6. PMID: 9382840
11. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling.  |  Pan, G., et al. 1998. FEBS Lett. 424: 41-5. PMID: 9537512
12. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor.  |  Pan, G., et al. 1998. FEBS Lett. 431: 351-6. PMID: 9714541

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DcR3 Antibody (F-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DcR3 Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DcR3 Antibody (F-4) Specifications

Alternate Product Name: DcR3

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 279-300

Epitope Target: DcR3 (decoy receptor 3)

Epitope Species: human

Product Reactivity/Detection: DcR3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DcR3 Antibody (F-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin