CREM Antibody (22): sc-101530

CREM Antibody (22) is a mouse monoclonal IgG1 kappa light chain antibody engineered to detect CREM, also known as cAMP response element modulator, of human origin across a variety of applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-CREM antibody (22) is raised against recombinant human CREM and is available in both non-conjugated form and multiple conjugated forms such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® variants, catering to diverse experimental requirements. CREM is a critical member of the ATF/CREB family of transcription factors, which regulate gene transcription by binding to cAMP response elements within promoter and enhancer regions. CREM undergoes essential post-translational modifications, including phosphorylation, which play a vital role in modulating transcriptional activity, stability, and interactions with other proteins. These modifications are crucial for CREM′s involvement in key biological processes, such as male fertility, where CREM function is indispensable, as evidenced by infertility in male mice lacking a functional CREM gene. In the testis, CREM′s transcriptional activity is regulated through interaction with the tissue-specific partner ACT (activator of CREM in the testis), and this interaction is further controlled by the testis-specific kinesin KIF17b, highlighting the significance of post-translational regulation. Additionally, CREM (22) monoclonal antibody exhibits reactivity with CREM proteins from other species, including canine and Syrian hamster, enhancing utility in comparative studies. By enabling detailed investigation of CREM′s role in gene expression and regulation through post-translational modifications, CREM (22) antibody serves as an essential tool for researchers exploring cellular signaling pathways and reproductive biology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CREM Antibody (22) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CREM Antibody (22) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CREM Antibody (22) Specifications

Alternate Product Name: CREM

Product Clone Name: 22

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: CREM

Epitope Species: human

Product Reactivity/Detection: CREM

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CREM Antibody (22): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred CREB1 antibody is CREB1 Antibody (D-12): sc-377154.