CGGBP1 Antibody (G-12): sc-398347

CGGBP1 Antibody (G-12) is a mouse monoclonal IgG3 antibody that detects CGGBP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CGGBP1, also known as CGG triplet repeat binding protein 1, is a crucial 167 amino acid nuclear protein that plays a significant role in regulating the expression of the FMR1 gene, which is essential for normal cognitive function. CGGBP1 is predominantly expressed in tissues such as the thymus, placenta, lymph nodes, cerebral cortex, and cerebellum, where anti-CGGBP1 antibody (G-12) can detect binding to the 5′ (CGG)n-3′ repeat in the promoter region of the FMR1 gene, thereby positively influencing the expression of the FMR1 protein. The interaction between CGGBP1 and the FMR1 promoter is critical, as cytosine-specific DNA methylation of the protein binding motif inhibits this interaction, leading to the transcriptional silencing observed in individuals affected by fragile X syndrome. Understanding CGGBP1 function and its regulatory role in FMR1 expression is vital, as this knowledge provides insights into the molecular mechanisms underlying fragile X syndrome and highlights potential therapeutic targets for intervention. CGGBP1 monoclonal antibody (G-12) serves as an invaluable tool for researchers investigating the complexities of gene regulation and the pathophysiology of fragile X syndrome.

The preferred CGGBP1 antibody is CGGBP1 Antibody (G-8): sc-376482.