CD69 Antibody (E-10): sc-515604

CD69 Antibody (E-10) is a mouse monoclonal IgG1 antibody that detects CD69 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD69 is a crucial early activation marker expressed as a disulfide-linked homodimer, known as the activation inducer molecule (AIM), which consists of two differentially glycosylated forms of a single protein. Anti-CD69 antibody (E-10) plays a significant role in studying immune response, as CD69 is one of the first antigens to appear following the activation of T cells, B cells, and natural killer (NK) cells. CD69 expression on activated lymphocytes indicates their readiness to respond to pathogens, making CD69 an important marker for studying immune activation and regulation. CD69 is constitutively expressed on platelets, CD4+ or CD8+ thymocytes, and germinal center T cells, while being absent from resting lymphocytes, highlighting CD69′s role in distinguishing between activated and non-activated immune cells. CD69 monoclonal antibody (E-10) effectively identifies CD69 in various applications, making CD69 (E-10) antibody an invaluable tool for researchers investigating immune responses and related disorders.

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CD69 Antibody (E-10) References:

1. CD69 modulates sphingosine-1-phosphate-induced migration of skin dendritic cells.  |  Lamana, A., et al. 2011. J Invest Dermatol. 131: 1503-12. PMID: 21412255
2. CD69 is a TGF-β/1α,25-dihydroxyvitamin D3 target gene in monocytes.  |  Wöbke, TK., et al. 2013. PLoS One. 8: e64635. PMID: 23696902
3. Generation of cancer-specific CD8(+) CD69(+) cells inhibits colon cancer growth.  |  Lan, B., et al. 2016. Immunobiology. 221: 1-5. PMID: 26314763
4. Distinct recirculation potential of CD69+CD103- and CD103+ thymic memory CD8+ T cells.  |  Park, SL., et al. 2016. Immunol Cell Biol. 94: 975-980. PMID: 27328704
5. Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings.  |  Yun, Y., et al. 2020. Allergol Int. 69: 232-238. PMID: 31928947
6. CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma.  |  Gršković, P., et al. 2022. Immunobiology. 227: 152257. PMID: 35964344
7. The roles of toll-like receptor 4, CD33, CD68, CD69, or CD147/EMMPRIN for monocyte activation by the DAMP S100A8/S100A9.  |  Möller, A., et al. 2023. Front Immunol. 14: 1110185. PMID: 37056775
8. The involvement of circulating CD69+ CD56bright natural killer cells in weight loss before bariatric surgery: A retrospective cohort study.  |  Chikuie, E., et al. 2023. Medicine (Baltimore). 102: e34999. PMID: 37832122
9. CXCR6+CD69+ CD8+ T cells in ascites are associated with disease severity in patients with cirrhosis.  |  Niehaus, C., et al. 2024. JHEP Rep. 6: 101074. PMID: 38882602
10. CD69+CD103+CD8+ tissue-resident memory T cells possess stronger anti-tumor activity and predict better prognosis in colorectal cancer.  |  Wu, ZX., et al. 2024. Cell Commun Signal. 22: 608. PMID: 39696312

The preferred CD69 antibody is CD69 Antibody (D-3): sc-373799.