CD4 Antibody (RM4-5): sc-19643

CD4 Antibody (RM4-5) is a rat monoclonal IgG2a antibody engineered to specifically recognize the mouse CD4 protein, also known as T4 or Leu 3. Anti-CD4 antibody (RM4-5) is raised against BALB/c mouse thymocytes and is recommended for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM) applications, ensuring reliable detection of CD4 of mouse origin. CD4 is a membrane-bound glycoprotein prominently expressed on the surface of T helper cells, as well as on cortical cells, mature medullary thymocytes, microglial cells, and dendritic cells. Located on the cell membrane, CD4 plays a critical role in the immune system by acting as a co-receptor for the T cell receptor (TCR), enhancing the interaction between TCRs and class II major histocompatibility complex (MHC) molecules presented by antigen-presenting cells. This interaction is essential for effective T cell activation and the subsequent immune response against pathogens. Additionally, CD4 serves as a primary receptor for the human immunodeficiency virus (HIV), making CD4 a key target for studies on viral entry and immune system dysfunction. CD4 monoclonal antibody (RM4-5) supports vital research in immunology, including investigations into autoimmune diseases, infectious diseases, and the development of immunotherapies. Anti-CD4 antibody (RM4-5) is recommended for scientists seeking to explore the complexities of immune function and disease mechanisms, providing robust performance and consistent results across multiple experimental platforms.

The preferred CD4 antibody is CD4 Antibody (GK1.5): sc-13573.