cadherin-23 Antibody (G-11): sc-166005
- cadherin-23 Antibody (G-11) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 151-450 mapping within an extracellular domain of cadherin-23 of human origin
- recommended for detection of cadherin-23 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for cadherin-23 Antibody (G-11) for WB applications. This reagent is now offered in a bundle with cadherin-23 Antibody (G-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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cadherin-23 Antibody (G-11) is a mouse monoclonal IgG1 antibody that detects cadherin-23 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cadherin-23 plays a crucial role in cell adhesion and is essential for the proper functioning of hair cells in the inner ear, where cadherin-23 forms a complex with myosin VIIIa and harmonin, facilitating hair cell differentiation and maintaining the integrity of the auditory system. Mutations in cadherin-23′s extracellular calcium-binding domain are linked to Usher syndrome type 1D, a genetic disorder characterized by hearing loss, balance issues, and progressive vision loss due to retinitis pigmentosa. The presence of various splice variants of cadherin-23 suggests that different mutations can lead to a range of phenotypic expressions, highlighting the importance of cadherin-23 in both auditory and visual systems. Anti-cadherin-23 antibody (G-11) is an invaluable tool for researchers studying the molecular mechanisms underlying these conditions and the functional dynamics of cadherin-23 in cellular contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cadherin-23 Antibody (G-11) | sc-166005 | 200 µg/ml | $322.00 | |||
cadherin-23 Antibody (G-11): m-IgGκ BP-HRP Bundle | sc-552279 | 200 µg Ab; 40 µg BP | $361.00 |