Date published: 2026-4-24

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Bufrolin (CAS 54867-56-0)

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Alternate Names:
6-Butyl-1,4,7,10-tetrahydro-4,10-dioxo-1,7-phenanthroline-2,8-dicarboxylic acid
CAS Number:
54867-56-0
Molecular Weight:
356.33
Molecular Formula:
C18H16N2O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Bufrolin, a naturally occurring compound found in the skin of specific frogs and toads, is a small peptide renowned for its diverse biological activities. Bufrolin has demonstrated remarkable anti-inflammatory properties, as well as an ability to modulate the immune system. Bufrolin engages with various pathways within the body. Studies suggest its interaction with the endocannabinoid system, responsible for managing stress and pain responses, as well as its influence on the serotonin and dopamine systems, which play pivotal roles in mood and behavior.


Bufrolin (CAS 54867-56-0) References

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  2. GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents.  |  Zafar, A., et al. 2017. Molecules. 22: PMID: 29258235
  3. Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation.  |  Mackenzie, AE., et al. 2019. FASEB J. 33: 5005-5017. PMID: 30601679
  4. G Protein-Coupled Receptor GPR35 Suppresses Lipid Accumulation in Hepatocytes.  |  Lin, LC., et al. 2021. ACS Pharmacol Transl Sci. 4: 1835-1848. PMID: 34927014
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  7. Other pharmacologic agents that may affect bronchial hyperreactivity.  |  Furukawa, CT. 1984. J Allergy Clin Immunol. 73: 693-8. PMID: 6143771
  8. Antigen-induced histamine release from sensitized tissue and the measurement of calcium ion fluxes.  |  Barrett-Bee, K. 1981. Biochem Biophys Res Commun. 98: 397-403. PMID: 6164363
  9. Passive anaphylaxis in human lung fragments as a model for testing anti-allergic drugs: its variability and constraints.  |  Young, KD. and Church, MK. 1983. Int Arch Allergy Appl Immunol. 70: 138-42. PMID: 6185440
  10. The characteristics of inhibition of histamine release from human lung fragments by sodium cromoglycate, salbutamol and chlorpromazine.  |  Church, MK. and Young, KD. 1983. Br J Pharmacol. 78: 671-9. PMID: 6189542
  11. Human leukocyte alkaline phosphatase inhibition by allergic mediator release inhibitors.  |  Schwender, CF. 1981. Biochem Pharmacol. 30: 217-22. PMID: 7225139
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Bufrolin, 10 mg

sc-504326
10 mg
$401.00