Date published: 2025-9-8

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BRCA1 Anticorpo (D-9): sc-6954

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Fichas de dados
  • BRCA1 Anticorpo D-9é um anticorpo monoclonal produzido em camundongo IgG2a κ BRCA1 anticorpo, citado em 454 publicações, fornecido em 200 µg/ml
  • específico para um epítopo mapeado entre os aminoácidos1843-1862 no C-terminus de BRCA1 de human origem
  • BRCA1 Anticorpo (D-9) é recomendado para a detecção de BRCA1 of human origin by WB, IP, IF and ELISA
  • Anticorpo anti-BRCA1 O anticorpo anti-BRCA1 (D-9) está disponível conjugado com agarose para IP; HRP para WB, IHC(P) e ELISA; e com fioeritrina ou FITC para IF, IHC(P) e FCM
  • também disponível conjugado com Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 ou Alexa Fluor® 647 para WB (RGB), IF, IHC(P) e FCM, e para utilização com sistemas de imagiologia fluorescente RGB, tais como iBright™ FL1000, FluorChem™, Typhoon, Azure e outros sistemas comparáveis
  • também disponível conjugado com Alexa Fluor® 680 ou Alexa Fluor® 790 para WB (NIR), IF e FCM; para utilização com sistemas de deteção de infravermelhos próximos (NIR), tais como LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure e outros sistemas comparáveis
  • Entre em contato conosco e receba GRATUITAMENTE um amostra de 10 µg de BRCA1 (D-9): sc-6954.
  • m-IgG Fc BP-HRP, 2a BP-HRP">m-IgG2a BP-HRP e m-IgGκ BP-HRP são os reagentes de deteção secundários preferidos para BRCA1 Antibody (D-9) para aplicações WB. Estes reagentes são agora oferecidos em pacotes com BRCA1 Antibody (D-9)(ver informações de encomenda abaixo).

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VEJA TAMBÉM

O anticorpo BRCA1 (D-9) é um anticorpo monoclonal de cadeia leve IgG2a kappa de camundongo que detecta BRCA1 de origem humana por western blotting, imunoprecipitação, imunofluorescência e ensaio de imunoabsorção enzimática. O anticorpo BRCA1 (D-9) está disponível em formas não conjugadas e em várias formas conjugadas, incluindo agarose, peroxidase de rábano, ficoeritrina, isotiocianato de fluoresceína e vários conjugados Alexa Fluor®. O BRCA1, identificado em 1990 e localizado no cromossoma 17q, desempenha um papel crucial na manutenção da estabilidade genómica e é essencial para os processos de reparação do ADN. As mutações BRCA1 estão alteradas em cerca de 45% das famílias com uma incidência elevada de cancro da mama e em pelo menos 80% das famílias com taxas elevadas de cancro da mama de início precoce e de cancro do ovário. Ao contrário do BRCA2, que está localizado no cromossoma 13q13.1, o BRCA1 é um supressor tumoral significativo que regula negativamente o crescimento tumoral, o que torna o BRCA1 vital na prevenção do cancro. O BRCA1, constituído por 1863 aminoácidos, apresenta um domínio de dedo de zinco na sua região amino-terminal, que é fundamental para a interação com outras proteínas envolvidas na reparação do ADN e na regulação do ciclo celular. O anticorpo monoclonal BRCA1 (D-9) pode fornecer informações valiosas sobre os mecanismos do cancro da mama e do ovário, bem como implicações mais amplas do BRCA1 na biologia tumoral.

Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.

Alexa Fluor® é uma marca comercial da Molecular Probes Inc., OR., EUA

LI-COR® e Odyssey® são marcas registadas da LI-COR Biosciences

Referencias do BRCA1 Anticorpo (D-9):

  1. BRCA1 interage física e funcionalmente com ATF1.  |  Houvras, Y., et al. 2000. J Biol Chem. 275: 36230-7. PMID: 10945975
  2. BRCA1 coopera com NUFIP e P-TEFb para ativar a transcrição pela RNA polimerase II.  |  Cabart, P., et al. 2004. Oncogene. 23: 5316-29. PMID: 15107825
  3. Locus familiar do cancro da mama e do ovário no cromossoma 17q12-q23.  |  Narod, SA., et al. 1991. Lancet. 338: 82-3. PMID: 1676470
  4. Ligação do cancro da mama familiar de início precoce ao cromossoma 17q21.  |  Hall, JM., et al. 1990. Science. 250: 1684-9. PMID: 2270482
  5. Um forte candidato para o gene de suscetibilidade ao cancro da mama e do ovário BRCA1.  |  Miki, Y., et al. 1994. Science. 266: 66-71. PMID: 7545954
  6. Mutações BRCA1 em carcinomas primários da mama e do ovário.  |  Futreal, PA., et al. 1994. Science. 266: 120-2. PMID: 7939630
  7. O gene do cancro da mama oferece surpresas.  |  Nowak, R. 1994. Science. 265: 1796-9. PMID: 8091205
  8. Localização de um gene de suscetibilidade ao cancro da mama, BRCA2, no cromossoma 13q12-13.  |  Wooster, R., et al. 1994. Science. 265: 2088-90. PMID: 8091231
  9. Redistribuição nuclear de BRCA1 durante a infeção viral.  |  Maul, GG., et al. 1998. Cell Growth Differ. 9: 743-55. PMID: 9751118

Informacoes sobre ordens

Nome do ProdutoNumero de CatalogoUNIDPrecoQdeFAVORITOS

BRCA1 Anticorpo (D-9)

sc-6954
200 µg/ml
$316.00

Pacote do BRCA1 (D-9): m-IgG Fc BP-HRP

sc-528169
200 µg Ab; 10 µg BP
$354.00

Pacote do BRCA1 (D-9): m-IgGκ BP-HRP

sc-520481
200 µg Ab, 40 µg BP
$354.00

Pacote do BRCA1 (D-9): m-IgG2a BP-HRP

sc-547036
200 µg Ab; 10 µg BP
$354.00

BRCA1 Anticorpo (D-9) AC

sc-6954 AC
500 µg/ml, 25% agarose
$416.00

BRCA1 Anticorpo (D-9) HRP

sc-6954 HRP
200 µg/ml
$316.00

BRCA1 Anticorpo (D-9) FITC

sc-6954 FITC
200 µg/ml
$330.00

BRCA1 Anticorpo (D-9) PE

sc-6954 PE
200 µg/ml
$343.00

BRCA1 Anticorpo (D-9) Alexa Fluor® 488

sc-6954 AF488
200 µg/ml
$357.00

BRCA1 Anticorpo (D-9) Alexa Fluor® 546

sc-6954 AF546
200 µg/ml
$357.00

BRCA1 Anticorpo (D-9) Alexa Fluor® 594

sc-6954 AF594
200 µg/ml
$357.00

BRCA1 Anticorpo (D-9) Alexa Fluor® 647

sc-6954 AF647
200 µg/ml
$357.00

BRCA1 Anticorpo (D-9) Alexa Fluor® 680

sc-6954 AF680
200 µg/ml
$357.00

BRCA1 Anticorpo (D-9) Alexa Fluor® 790

sc-6954 AF790
200 µg/ml
$357.00

BRCA1 (D-9) peptídeo neutralizante

sc-6954 P
100 µg/0.5 ml
$68.00

3–8% Tris-acetate gel로 HAP-1 cell에서 WB을 진행. Ponceau 결과에서 단백질은 잘 transfer되었고, actin 역시 정상적으로 발현이 확인되었습니다. 그러나 target인 BRCA1은 검출되지 않았습니다. 현재 사용 중인 transfer 조건은 400 mA, 90분 (wet transfer)이며, BRCA1이 고분자 단백질이다 보니 transfer 조건을 건드려야할 것 같은데, 조언해주실 부분 있을까요?

Asked by: WaterD
Thank you for your question. Please contact our Technical Service Department for more information. Our Asian Technical Service team is available at asia@scbio.cn or by live chat on our website.
Answered by: Technical Service SH
Date published: 2025-08-11

Hello, is this antibody sequence available for engineering purposes? Or, how do I go about collaborating with SC to get the proprietary sequence for academic research?

Asked by: Brant Gracia
The sequences are proprietary for our antibodies.
Answered by: Technical Service
Date published: 2024-10-11

Can the antibody be used at 37 oC for 1 h for western blot?

Asked by: Elisabet Ognedal
Thank you for your question. We do not recommend using the antibody at 37 C. Please see our protocol for recommendations. https://www.scbt.com/resources/protocols/western-immuno-blotting
Answered by: BlakeJ
Date published: 2024-09-27

I have tried an aliquote of sc-6954 (Lot-J0622), borrowed from a collegue, and I have got no signal at all in western blot. I wanted this ab because it has lots of citations. Could I get a sample of a different Lot to test it before buying it? Thanks.

Asked by: Israel
Thank you for your question. Please contact our technical service team directly.
Answered by: Tech Support Europe
Date published: 2024-09-03

What Is the recommended blocking buffer for this antibody(sc-6954)? We have tried LI-COR’s PBS based blocking buffer and 5% BSA in PBST, but have not detected the expected bands, despite detection of phospho-Brca1. We are using several Ewing sarcoma lines

Asked by: Hortonj
Thank you for your question. We recommend blocking in 5% milk with TBS-T, or our recommended UltraCruz blocking reagent, sc-516214. Please contact Technical Service if you need any further assistance with this antibody!
Answered by: Tech Service
Date published: 2019-01-14

I am saneesh Babu Padmasaras working as a postdoctoral fellow in Department of Biochemsitry and molecular biology, I would like to get a free sample 10 µg sample of BRCA1 Antibody (D-9): sc-6954 , so kindly send me the antibody

Asked by: Saneesh
Thank you for your question. Please contact Technical Service for information on how to obtain a sample.
Answered by: Technical Support
Date published: 2018-12-14

如何联系你们申请试用装?

Asked by: 张晨aaa
感谢您的提问。关于试用装的申请事宜,欢迎通过:电话(+86) 021-60936350、邮箱asia@scbio.cn、或选择网页上Live Chat中的“中文支持”,联系我们的技术支持部门。 Thank you for your inquiry. For sample request, please contact our Asian Technical Service team at (+86) 021-60936350 or asia@scbio.cn or by live chat on our website.
Answered by: Technical Support 15
Date published: 2018-02-11

Can BRCA1 Antibody (D-9) use for immunoprecipitation assey in human breast cancer cell lines? We are looking for papers.

Asked by: taro12345678
Thank you for your question. Yes, this mouse monoclonal, BRCA1 Antibody (D-9): sc-6954 can be used for immunoprecipitation (IP) on human cell lines. We are aware of a couple of publications citing use of the antibody for IP in human breast cancer cell lines. Please refer to PMID's: 27454289 and 25480944.
Answered by: Technical Support
Date published: 2017-06-26
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Rated 1 out of 5 by from Completely Blank BlotSC-6954, Lot# H1122, does not detect BRCA1 on western blot, even with 60µg whole cell extract from human HCT116 cells, 3-8% TA gel, 20% EtOH equilibration, 10' x 25V iblot transfer, and 1:100 O/N incubation. Positive control worked fine.
Date published: 2023-03-02
Rated 4 out of 5 by from Good for WBBy Western Blot (1:500 dilution), I can detect a clear band at the expected molecular weight.
Date published: 2022-11-07
Rated 1 out of 5 by from The antibody doesn't workWe just bought a new antibody to test by western blot. The wb is completely blank. other antibodies probing for the other protein works well (we do wb everyday). This antibody used to work during my postdoc research. Perhaps there's a change in production.
Date published: 2022-01-12
Rated 5 out of 5 by from Good antibody for western blottingI used this antibody for western blotting (1:100 dilution). A specific band was detected in cancer cell line as compared with BRCA1 KO cells.
Date published: 2021-12-23
Rated 5 out of 5 by from Works very wellWorks very well by immunofluorescence on cells (1:200 dilution). By western blot (1:1000 dilution) i can see a clear band with nuclear/cytoplasmic fractionation
Date published: 2021-11-26
Rated 5 out of 5 by from Great antibody for both IF and WBI have been using this anti-BRCA1 antibody for both IF and WB (1:100 dilution) for over a year now and couldn't be happier! Very specific (verified by knock-down in our lab) and good signal even with low protein expression.
Date published: 2021-01-04
Rated 1 out of 5 by from Failed to stain pachytene spermatocytesNo signal at all at 1:50, 1:100, 1:200 whatsoever. We tried goat and donkey serum - no difference. There were good reviews for the previous Ab C-20. C-20 was rabbite polyclonal and this one is mouse monoclonal, so I guess it skips a lot of signal. D-9 is probably good just for biochemistry. Example is the most recent paper that cited D-9 - in it D9 was used just for pull-downs and WB, but the cytology was done by C-20.
Date published: 2019-05-23
Rated 5 out of 5 by from 应该还不错你好,我在半年前买了BRCA1这个抗体,可能是我转膜时间不太对,跑了两次没有条带,我想请问一下,这种大分子的蛋白转条件应该如何把握,谢谢!
Date published: 2018-10-09
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BRCA1 Anticorpo (D-9) is rated 4.2 out of 5 by 53.
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