beta 3 Tubulin Antibody (2G10): sc-80005

β3 Tubulin Antibody (2G10) is a mouse monoclonal IgG2a kappa light chain antibody that detects beta 3 Tubulin protein of mouse, rat, human, and bovine origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. β3 Tubulin (2G10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Beta 3 Tubulin protein plays a crucial role in the structure and function of the cytoskeleton, specifically within neurons, where beta 3 Tubulin maintains the integrity of microtubules that support cellular shape and transport. Beta 3 Tubulin predominantly localizes in the cytoplasm of neurons, where beta 3 Tubulin contributes to the formation of microtubules vital for axonal growth and stability. Beta 3 Tubulin is particularly important in the development and function of the nervous system, as beta 3 Tubulin participates in processes such as neuronal differentiation and the establishment of synaptic connections. Beta 3 Tubulin expression serves as a marker for neuronal cells, making beta 3 Tubulin a valuable tool in neurobiological research and studies related to neurodegenerative diseases.

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beta 3 Tubulin Antibody (2G10) References:

1. Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1.  |  Fourest-Lieuvin, A., et al. 2006. Mol Biol Cell. 17: 1041-50. PMID: 16371510
2. Introduction of silencing-inducing transgene against Fgf19 does not affect expression of Tbx5 and beta3-tubulin in the developing chicken retina.  |  Okamoto, M., et al. 2008. Dev Growth Differ. 50: 159-68. PMID: 18312426
3. Beta3-tubulin is induced by estradiol in human breast carcinoma cells through an estrogen-receptor dependent pathway.  |  Saussede-Aim, J., et al. 2009. Cell Motil Cytoskeleton. 66: 378-88. PMID: 19466750
4. [Immunohistochemical study of human fetal vomerona structures the nasal septum, by applying neuron-specific beta3-tubulin antibodies].  |  Kharlamova, AS., et al. 2011. Arkh Patol. 73: 18-22. PMID: 21695983
5. β3-tubulin is a good predictor of sensitivity to taxane-based neoadjuvant chemotherapy in primary breast cancer.  |  Xiang, Y., et al. 2016. Clin Exp Med. 16: 391-7. PMID: 26088183
6. Beta3-Tubulin is Critical for Microtubule Dynamics, Cell Cycle Regulation, and Spontaneous Release of Microvesicles in Human Malignant Melanoma Cells (A375).  |  Altonsy, MO., et al. 2020. Int J Mol Sci. 21: PMID: 32121295
7. The phosphatase of regenerating liver-3 protein (PRL-3) promotes glioma cell invasiveness by interacting with β3 -tubulin.  |  Ge, Z., et al. 2022. Bioengineered. 13: 4112-4121. PMID: 35098869
8. Bone marrow mesenchymal stromal cells in a 3D system produce higher concentration of extracellular vesicles (EVs) with increased complexity and enhanced neuronal growth properties.  |  Jalilian, E., et al. 2022. Stem Cell Res Ther. 13: 425. PMID: 35986305
9. A CRISPR/Cas9-Based Assay for High-Throughput Studies of Cancer-Induced Innervation.  |  Galappaththi, SL., et al. 2023. Cancers (Basel). 15: PMID: 37046688
10. Neuroregeneration Improved by Sodium-D,L-Beta-Hydroxybutyrate in Primary Neuronal Cultures.  |  Ari, C., et al. 2024. Pharmaceuticals (Basel). 17: PMID: 39338322

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-β3 Tubulin Antibody (2G10) has 70 citations in a variety of scientific publications.

Primary antibodies like Anti-β3 Tubulin Antibody (2G10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

β3 Tubulin Antibody (2G10) Specifications

Alternate Product Name: Neuronal marker class 3 beta tubulin

Product Clone Name: 2G10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 436-450

Epitope Target: β3 Tubulin

Epitope Species: rat

Product Reactivity/Detection: neuronal specific β3 Tubulin

Species Reactivity/Detection: mouse, rat, human, bovine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 70 citations in various scientific publications

Available Conjugates/Forms for β3 Tubulin Antibody (2G10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred β3 Tubulin antibody is β3 Tubulin Antibody (TU-20): sc-51670.