β3 Tubulin Antibody (TU-20): sc-51670

β3 Tubulin Antibody (TU-20) is a mouse monoclonal IgG1 antibody that detects β3 Tubulin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. anti-β3 Tubulin antibody (TU-20) is offered in a non-conjugated form, specifically designed for researchers seeking to study this neuron-specific cytoskeletal protein. β3 Tubulin plays a crucial role in the development and function of the nervous system, as β3 Tubulin is predominantly expressed in neurons and is essential for maintaining the structural integrity of neuronal microtubules. These microtubules are vital for various cellular processes, including intracellular transport, cell shape maintenance, and the formation of neuronal networks. The unique expression pattern of β3 Tubulin, compared to other tubulin isoforms, highlights β3 Tubulin′s importance in neurogenesis and synaptic function, making β3 Tubulin a valuable marker for studying neurodevelopmental disorders and neurodegenerative diseases. β3 Tubulin monoclonal antibody (TU-20) enables researchers to gain insights into the dynamics of neuronal cytoskeletons and their implications in health and disease.

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β3 Tubulin Antibody (TU-20) References:

1. Presence of the betaII isotype of tubulin in the nuclei of cultured mesangial cells from rat kidney.  |  Walss, C., et al. 1999. Cell Motil Cytoskeleton. 42: 274-84. PMID: 10223634
2. Identification of betaIII- and betaIV-tubulin isotypes in cold-adapted microtubules from Atlantic cod (Gadus morhua): antibody mapping and cDNA sequencing.  |  Modig, C., et al. 1999. Cell Motil Cytoskeleton. 42: 315-30. PMID: 10223637
3. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function.  |  Chang, P. and Stearns, T. 2000. Nat Cell Biol. 2: 30-5. PMID: 10620804
4. Tubulin immunoreactive neuronal intranuclear inclusions in the human brain.  |  Woulfe, J. and Munoz, D. 2000. Neuropathol Appl Neurobiol. 26: 161-71. PMID: 10840279
5. Alpha-, beta-, and gamma-tubulins: sequence comparisons and structural constraints.  |  Burns, RG. 1991. Cell Motil Cytoskeleton. 20: 181-9. PMID: 1773446
6. Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome.  |  Zheng, Y., et al. 1991. Cell. 65: 817-23. PMID: 1904010
7. β3-tubulin is a good predictor of sensitivity to taxane-based neoadjuvant chemotherapy in primary breast cancer.  |  Xiang, Y., et al. 2016. Clin Exp Med. 16: 391-7. PMID: 26088183
8. Beta3-Tubulin is Critical for Microtubule Dynamics, Cell Cycle Regulation, and Spontaneous Release of Microvesicles in Human Malignant Melanoma Cells (A375).  |  Altonsy, MO., et al. 2020. Int J Mol Sci. 21: PMID: 32121295
9. The phosphatase of regenerating liver-3 protein (PRL-3) promotes glioma cell invasiveness by interacting with β3 -tubulin.  |  Ge, Z., et al. 2022. Bioengineered. 13: 4112-4121. PMID: 35098869
10. Invited review: the role of nucleotide triphosphate in actin and tubulin assembly and function.  |  Weisenberg, RC. 1981. Cell Motil. 1: 485-97. PMID: 6756643
11. Multiple forms of tubulin: different gene products and covalent modifications.  |  Ludueña, RF. 1998. Int Rev Cytol. 178: 207-75. PMID: 9348671
12. Expression of amino- and carboxyl-terminal gamma- and alpha-tubulin mutants in cultured epithelial cells.  |  Leask, A. and Stearns, T. 1998. J Biol Chem. 273: 2661-8. PMID: 9446570

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-β3 Tubulin Antibody (TU-20) has 89 citations in a variety of scientific publications.

Primary antibodies like Anti-β3 Tubulin Antibody (TU-20) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

β3 Tubulin Antibody (TU-20) Specifications

Alternate Product Name: Neuronal marker class 3 beta tubulin

Product Clone Name: TU-20

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 441-448

Epitope Target: β3 Tubulin

Epitope Species: human

Product Reactivity/Detection: β3 Tubulin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 89 citations in various scientific publications

Available Conjugates/Forms for β3 Tubulin Antibody (TU-20): N/A