beta-Arrestin-2 Antibody (F-2): sc-514791
- β-Arrestin-2 Antibody (F-2) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 250-270 near the C-terminus of β-Arrestin-2 of human origin
- recommended for detection of β-Arrestin-2 of mouse, rat and human origin by WB, IP, IF and ELISA
- See β-Arrestin-2 (B-4): sc-365445 for β-Arrestin-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for β-Arrestin-2 Antibody (F-2) for WB applications. These reagents are now offered in bundles with β-Arrestin-2 Antibody (F-2) (see ordering information below).
QUICK LINKS
SEE ALSO...
β-Arrestin-2 Antibody (F-2) is a mouse monoclonal IgG1 antibody that detects β-Arrestin-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). β-Arrestin-2 plays a crucial role in regulating G protein-coupled receptors (GPCRs), which are vital for various physiological processes, including neurotransmission and hormone signaling. β-Arrestin-2 is primarily located in the cytoplasm and at postsynaptic sites of neurons, where β-Arrestin-2 interacts with GPCRs to facilitate receptor desensitization and internalization, thereby modulating cellular responses to external signals. β-Arrestin-2′s cellular location enables scaffold formation for signaling complexes, influencing downstream signaling pathways and ensuring proper cellular communication. β-Arrestin-2 has been shown to interact with various proteins, including βARK (β-adrenergic receptor kinase), which further underscores β-Arrestin-2′s significance in regulating receptor-mediated signaling. β-Arrestin-2 expression is predominantly observed in spleen and neuronal tissues, and β-Arrestin-2′s modulation by intracellular cAMP levels highlights a novel mechanism for fine-tuning receptor responses, making β-Arrestin-2 a critical component in studying GPCR signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
beta-Arrestin-2 Antibody (F-2) References:
- Beta-arrestin 2 negatively regulates sepsis-induced inflammation. | Fan, H., et al. 2010. Immunology. 130: 344-51. PMID: 20465566
- β-Arrestin prevents cell apoptosis through pro-apoptotic ERK1/2 and p38 MAPKs and anti-apoptotic Akt pathways. | Yang, X., et al. 2012. Apoptosis. 17: 1019-26. PMID: 22699970
- Omega-3 Fatty Acids and FFAR4. | Oh, DY. and Walenta, E. 2014. Front Endocrinol (Lausanne). 5: 115. PMID: 25076939
- SUMOylation attenuates human β-arrestin 2 inhibition of IL-1R/TRAF6 signaling. | Xiao, N., et al. 2015. J Biol Chem. 290: 1927-35. PMID: 25425640
- β-Arrestin 2 dependence of Δ opioid receptor agonists is correlated with alcohol intake. | Chiang, T., et al. 2016. Br J Pharmacol. 173: 332-43. PMID: 26507558
- β-arrestin 2 quenches TLR signaling to facilitate the immune evasion of EPEC. | Chen, Z., et al. 2020. Gut Microbes. 11: 1423-1437. PMID: 32403971
- β-arrestin 2 as an activator of cGAS-STING signaling and target of viral immune evasion. | Zhang, Y., et al. 2020. Nat Commun. 11: 6000. PMID: 33243993
- β-Arrestin 2 and Epac2 Cooperatively Mediate DRD1-Stimulated Proliferation of Human Neural Stem Cells and Growth of Human Cerebral Organoids. | Dong, X., et al. 2022. Stem Cells. 40: 857-869. PMID: 35772103
- β-Arrestin 2 knockout prevents bone loss in response to continuous parathyroid hormone stimulation in male and female mice. | Li Feng, G., et al. 2023. Connect Tissue Res. 64: 350-361. PMID: 37046359
- Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages. | Wei, X., et al. 2024. Cell Metab. 36: 2281-2297.e7. PMID: 39305895
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-Arrestin-2 Antibody (F-2) | sc-514791 | 200 µg/ml | $322.00 | |||
β-Arrestin-2 Antibody (F-2): m-IgG Fc BP-HRP Bundle | sc-538701 | 200 µg Ab; 10 µg BP | $361.00 | |||
β-Arrestin-2 Antibody (F-2): m-IgGκ BP-HRP Bundle | sc-536363 | 200 µg Ab; 40 µg BP | $361.00 | |||
β-Arrestin-2 Antibody (F-2): m-IgG1 BP-HRP Bundle | sc-545842 | 200 µg Ab; 20 µg BP | $361.00 | |||
β-Arrestin-2 (F-2) Neutralizing Peptide | sc-514791 P | 100 µg/0.5 ml | $69.00 |