BCMA Antibody (D-6): sc-390147

BCMA Antibody (D-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects BCMA protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BCMA (D-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. B cell maturation protein (BCMA), also known as BCM and tumor necrosis factor receptor superfamily member 17, is a type I integral membrane protein encoded by a gene located on chromosome band 16p13.1. BCMA protein plays a crucial role in the survival and differentiation of B cells, as BCMA is specifically expressed in mature B lymphocytes and is localized to the cis part of the Golgi apparatus. BCMA protein is essential for regulating B cell homeostasis and has been implicated in various immune responses, particularly in autoimmune diseases and B cell malignancies. BCMA protein interacts with APRIL and TALL-1, which are important for B cell proliferation and survival, highlighting BCMA′s significance in maintaining B cell populations and influencing immune system dynamics. BCMA′s structural features, including a cysteine-rich domain, allow BCMA to share significant homology with TACI (transmembrane activator), further underscoring BCMA′s role in B cell signaling pathways.

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BCMA Antibody (D-6) References:

1. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease.  |  Gross, JA., et al. 2000. Nature. 404: 995-9. PMID: 10801128
2. A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma.  |  Laâbi, Y., et al. 1992. EMBO J. 11: 3897-904. PMID: 1396583
3. IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-beta, IL-28, and IL-29.  |  Sirén, J., et al. 2005. J Immunol. 174: 1932-7. PMID: 15699120
4. IFN-lambda: novel antiviral cytokines.  |  Ank, N., et al. 2006. J Interferon Cytokine Res. 26: 373-9. PMID: 16734557
5. IL-28 and IL-29: newcomers to the interferon family.  |  Uzé, G. and Monneron, D. 2007. Biochimie. 89: 729-34. PMID: 17367910
6. Identification of new splice variants of the genes BAFF and BCMA.  |  Smirnova, AS., et al. 2008. Mol Immunol. 45: 1179-83. PMID: 17825416
7. Role of Interferon-λ in Allergic Asthma.  |  Koch, S. and Finotto, S. 2015. J Innate Immun. 7: 224-30. PMID: 25592858
8. Interleukin 28 is a potential therapeutic target for sepsis.  |  Luo, Q., et al. 2019. Clin Immunol. 205: 29-34. PMID: 31121287
9. The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed.  |  Laabi, Y., et al. 1994. Nucleic Acids Res. 22: 1147-54. PMID: 8165126
10. BCMAp: an integral membrane protein in the Golgi apparatus of human mature B lymphocytes.  |  Gras, MP., et al. 1995. Int Immunol. 7: 1093-106. PMID: 8527407
11. NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.  |  von Bülow, GU. and Bram, RJ. 1997. Science. 278: 138-41. PMID: 9311921
12. The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily.  |  Madry, C., et al. 1998. Int Immunol. 10: 1693-702. PMID: 9846698

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BCMA Antibody (D-6) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-BCMA Antibody (D-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BCMA Antibody (D-6) Specifications

Alternate Product Name: BCMA

Product Clone Name: D-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 108-161

Epitope Target: BCMA

Epitope Species: human

Product Reactivity/Detection: BCMA

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for BCMA Antibody (D-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin