Bacitracin A (CAS 22601-59-8)
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Bacitracin A (8CI) is a remarkable polypeptide antibiotic produced by various bacteria, including Bacillus subtilis. Its versatility as an antimicrobial agent has found applications in diverse fields, ranging from wound care to food preservation. Comprised of amino acids like alanine, lysine, and threonine, this antibiotic exhibits notable inhibitory effects against Gram-positive bacteria, such as Staphylococcus aureus and Streptococcus pyogenes. The effectiveness of Bacitracin A (8CI) lies in its ability to selectively bind to specific cell wall components of Gram-positive bacteria. By targeting peptidoglycan, a vital component of the bacterial cell wall, Bacitracin A (8CI) disrupts the structural integrity, impairing bacterial survival. Additionally, this antibiotic hinders the production of essential proteins for bacterial growth and reproduction.
Bacitracin A (CAS 22601-59-8) References
- A bacitracin-resistant Bacillus subtilis gene encodes a homologue of the membrane-spanning subunit of the Bacillus licheniformis ABC transporter. | Ohki, R., et al. 2003. J Bacteriol. 185: 51-9. PMID: 12486040
- Structure of bacitracin A. | LOCKHART, IM., et al. 1954. Nature. 173: 536-7. PMID: 13154372
- Detection of residual bacitracin A, colistin A, and colistin B in milk and animal tissues by liquid chromatography tandem mass spectrometry. | Wan, EC., et al. 2006. Anal Bioanal Chem. 385: 181-8. PMID: 16547744
- Conformational analysis of bacitracin A, a naturally occurring lariat. | Pons, M., et al. 1991. Biopolymers. 31: 605-12. PMID: 1932561
- Validation of a quantitative HPLC method for bacitracin and bacitracin zinc using EDTA as a mobile-phase modifier. | Potts, AR., et al. 2012. J Pharm Biomed Anal. 70: 619-23. PMID: 22795823
- Photooxidation of the Antimicrobial, Nonribosomal Peptide Bacitracin A by Singlet Oxygen under Environmentally Relevant Conditions. | Lundeen, RA., et al. 2016. Environ Sci Technol. 50: 8586-95. PMID: 27128169
- Up Scaling Strategies to Improve the Industrial Production of Bacitracin at Largescale. | Sharma, CK. and Sharma, M. 2017. Mini Rev Med Chem. 17: 1548-1556. PMID: 28699496
- Bacitracin: A Causative Agent of Purpuric Allergic Contact Dermatitis. | Ertugrul, A. and Kabatas, EU. 2020. Pediatr Allergy Immunol Pulmonol. 33: 213-215. PMID: 35921563
- Retraction Note To: Pluronic-based nano-self-assemblies of bacitracin A with a new mechanism of action for an efficient in vivo therapeutic effect against bacterial peritonitis. | Hong, W., et al. 2022. J Nanobiotechnology. 20: 408. PMID: 36100941
- Synthetic Studies with Bacitracin A and Preparation of Analogues Containing Alternative Zinc Binding Groups. | Buijs, N., et al. 2022. Chembiochem. 23: e202200547. PMID: 36287040
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bacitracin A, 1 mg | sc-506575 | 1 mg | $183.00 | |||
Bacitracin A, 5 mg | sc-506575A | 5 mg | $640.00 | |||
Bacitracin A, 25 mg | sc-506575B | 25 mg | $3121.00 |