APLNR Antibody (3C3-7): sc-517300
- APLNR Antibody (3C3-7) is a mouse monoclonal IgG1 κ APLNR antibody, cited in 8 publications, provided at 200 µg/ml
- raised against full-length recombinant APLNR of human origin
- APLNR Antibody (3C3-7) is recommended for detection of APLNR of mouse, rat and human origin by WB, IP, IF and IHC(P); also reactive with additional species, including and bovine, porcine, caprine and canine
- Anti-APLNR Antibody (3C3-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for APLNR Antibody (3C3-7) for WB and IHC(P) applications. These reagents are now offered in bundles with APLNR Antibody (3C3-7) (see ordering information below).
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APLNR Antibody (3C3-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects the APLNR protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-APLNR antibody (3C3-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The apelin receptor (APLNR) is a G protein-coupled receptor that plays a crucial role in cardiovascular regulation and energy homeostasis. APLNR is primarily located in the hypothalamus, where APLNR is involved in the modulation of neuroendocrine functions, including the regulation of appetite and blood pressure. APLNR presence in glial cells, astrocytes, and specific neuronal populations highlights APLNR importance in central nervous system signaling pathways. APLNR is activated by its endogenous ligand, apelin, which leads to receptor internalization and subsequent signaling events that can inhibit cAMP production, thereby influencing various physiological responses. APLNR also serves as an alternative coreceptor for HIV-1, indicating APLNR multifaceted role in both health and disease. Understanding APLNR localization and function is essential for elucidating APLNR contributions to metabolic and cardiovascular disorders, making APLNR monoclonal antibody (3C3-7) a valuable tool for researchers studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
APLNR Antibody (3C3-7) References:
- Cloning, pharmacological characterization and brain distribution of the rat apelin receptor. | De Mota, N., et al. 2000. Neuroendocrinology. 72: 400-7. PMID: 11146423
- Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain. | Reaux, A., et al. 2001. J Neurochem. 77: 1085-96. PMID: 11359874
- APJ receptor mRNA expression in the rat hypothalamic paraventricular nucleus: regulation by stress and glucocorticoids. | O'Carroll, AM., et al. 2003. J Neuroendocrinol. 15: 1095-101. PMID: 14622440
- Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors. | Lee, DK., et al. 2004. J Biol Chem. 279: 7901-8. PMID: 14645236
- Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure. | El Messari, S., et al. 2004. J Neurochem. 90: 1290-301. PMID: 15341513
- Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells. | Kleinz, MJ., et al. 2005. Regul Pept. 126: 233-40. PMID: 15664671
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
APLNR Antibody (3C3-7) | sc-517300 | 200 µg/ml | $322.00 | |||
APLNR Antibody (3C3-7): m-IgG Fc BP-HRP Bundle | sc-531579 | 200 µg Ab; 10 µg BP | $361.00 | |||
APLNR Antibody (3C3-7): m-IgGκ BP-HRP Bundle | sc-525308 | 200 µg Ab, 40 µg BP | $361.00 | |||
APLNR Antibody (3C3-7): m-IgG1 BP-HRP Bundle | sc-544636 | 200 µg Ab; 20 µg BP | $361.00 | |||
APLNR Antibody (3C3-7) AC | sc-517300 AC | 500 µg/ml, 25% agarose | $424.00 | |||
APLNR Antibody (3C3-7) HRP | sc-517300 HRP | 200 µg/ml | $322.00 | |||
APLNR Antibody (3C3-7) FITC | sc-517300 FITC | 200 µg/ml | $336.00 | |||
APLNR Antibody (3C3-7) PE | sc-517300 PE | 200 µg/ml | $349.00 | |||
APLNR Antibody (3C3-7) Alexa Fluor® 488 | sc-517300 AF488 | 200 µg/ml | $364.00 | |||
APLNR Antibody (3C3-7) Alexa Fluor® 546 | sc-517300 AF546 | 200 µg/ml | $364.00 | |||
APLNR Antibody (3C3-7) Alexa Fluor® 594 | sc-517300 AF594 | 200 µg/ml | $364.00 | |||
APLNR Antibody (3C3-7) Alexa Fluor® 647 | sc-517300 AF647 | 200 µg/ml | $364.00 | |||
APLNR Antibody (3C3-7) Alexa Fluor® 680 | sc-517300 AF680 | 200 µg/ml | $364.00 | |||
APLNR Antibody (3C3-7) Alexa Fluor® 790 | sc-517300 AF790 | 200 µg/ml | $364.00 |