Date published: 2026-4-25

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Apelin Receptor Activators

Santa Cruz Biotechnology now offers a broad range of Apelin Receptor Activators for use in various applications. Apelin receptor activators are a vital category of chemicals that have become increasingly important in scientific research, particularly in the study of cardiovascular physiology, fluid homeostasis, and energy metabolism. The apelin receptor, also known as APJ, is a G-protein-coupled receptor that interacts with the endogenous peptide apelin, playing a significant role in various biological processes, including regulation of blood pressure, cardiac contractility, and fluid balance. By using apelin receptor activators, researchers can precisely stimulate this receptor to investigate its signaling pathways and understand its contribution to these critical physiological functions. These activators are essential tools for exploring the role of the apelin-APJ axis in regulating cardiovascular health and its potential impact on conditions such as hypertension, heart failure, and metabolic disorders. Furthermore, apelin receptor activators are used in studies focused on the receptor's involvement in angiogenesis, cell proliferation, and tissue remodeling, providing valuable insights into how the apelin-APJ system influences cellular behavior and organ function. The use of these activators extends to research in neurobiology and endocrinology, where the apelin receptor is implicated in the regulation of fluid intake, energy expenditure, and insulin sensitivity. The availability of a broad range of apelin receptor activators allows scientists to design experiments tailored to specific aspects of apelin receptor signaling, advancing our understanding of its physiological roles and potential applications in various fields of biological research. View detailed information on our available Apelin Receptor Activators by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

(Glp1)-Apelin-13

217082-60-5sc-359030
1 mg
$161.00
2
(1)

(Glp1)-Apelin-13 functions as a potent ligand for the Apelin receptor, engaging in specific molecular interactions that activate intracellular signaling pathways. Its unique peptide structure facilitates binding through hydrogen bonding and hydrophobic interactions, enhancing receptor affinity. This activation triggers downstream effects, including modulation of cellular responses and metabolic processes. The compound's conformational dynamics contribute to its selective receptor engagement, influencing biological outcomes.

Apelin-13

217082-58-1sc-351718
sc-351718A
sc-351718B
sc-351718C
1 mg
5 mg
10 mg
25 mg
$98.00
$405.00
$619.00
$1348.00
19
(1)

Apelin-13 serves as a key ligand for the Apelin receptor, characterized by its distinct peptide sequence that promotes specific conformational changes upon binding. This interaction initiates a cascade of intracellular signaling, primarily through G-protein coupled pathways. The peptide's structural flexibility allows for optimal receptor fit, enhancing its efficacy. Additionally, Apelin-13's role in modulating ion channel activity and cellular calcium levels underscores its importance in physiological regulation.

ML-233

sc-487760
10 mg
$340.00
(0)

ML-233 is a selective modulator of the Apelin receptor, exhibiting unique binding dynamics that enhance receptor activation. Its structural conformation facilitates specific interactions with receptor sites, promoting distinct signaling pathways. The compound's kinetic profile reveals rapid association and dissociation rates, allowing for fine-tuned regulation of downstream effects. Furthermore, ML-233's ability to influence cellular responses through modulation of second messengers highlights its intricate role in receptor-mediated processes.