Ambroxol hydrochloride CAS: 23828-92-4
MF: C13H18Br2N2O•HCl
MW: 414.6
An expectorant antioxidant and antiinflammatory agent.

Ambroxol hydrochloride (CAS 23828-92-4)

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Aplicação An expectorant antioxidant and antiinflammatory agent
Numero VAT: 23828-92-4
Privada: 98%
Peso Molecular: 414.6
Separar por Funcao: C13H18Br2N2O•HCl
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Ambroxol hydrochloride is a small molecule expectorant and mucolytic agent with antioxidant and antiinflammatory effects. Ambroxol stimulates the secretion of surfactant which decreases mucus adhesion to the bronchial lining and produces expectorant effects. The antioxidant effects of Ambroxol are well demonstrated, where lipid peroxidation initiated by t-butyl hydroperoxide or doxorubicin is suppressed in the presence Ambroxol, and scavenging of hydroxyl radicals and cellular superoxide radical anions is also observed. Ambroxol produces antiinflammatory effects by blocking the expression of proinflammatory messengers, inhibiting the release of histamine from mast cells and the generation of cytokines and interleukins. Ambroxol hydrochloride is an inhibitor of Sodium Channel Protein.


Referencias

1. Disse, B.G. 1987. Eur J Respir Dis Suppl. 153: 255-262. PMID: 3322865
2. Wilke, A., et al. 1987. Respiration. 52: 129-136. PMID: 3671891
3. Nowak, D., et al. 1995. Free Radic. Biol. Med. 19: 659-663. PMID: 8529925
4. Gibbs, B.F., et al. 1999. Inflamm. Res. 48: 86-93. PMID: 10202994
5. Stetinová, V., et al. 2004. Clin. Exp. Med. 4: 152-158. PMID: 15599665
6. Laurent, A., et al. 2004. Hepatology. 39: 1277-1285. PMID: 15122756
7. Su, X., et al. 2004. Intensive Care Med. 30: 133-140. PMID: 14504727
8. Beeh, K.M., et al. 2008. Eur. J. Med. Res. 13: 557-562. PMID: 19073395
9. Malerba, M., 2008. Expert Opin Drug Metab Toxicol. 4: 1119-1129. PMID: 18680446

Aparência :
Crystalline powder
Estado físico :
Solid
envie :
Soluble in methanol, water (~5 mg/ml), ethanol (~5 mg/ml), and DMSO (50 mM). Insoluble in ether.
Manutencao :
Store at 4° C
Ponto de fusão :
>235° C (dec.)
IC50 :
tetrodotoxin (TTX)-resistant channels: IC50 = 35.2 µM; TTX-sensitive subtypes: IC50 = 111.5 µM
Valores de pK :
pKb: 8.69
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
RTECS :
GV8423000
PubChem CID :
108013
Indice de produtos :
14: 386
Numero de FAX :
MFCD00078932
Numero de FAX :
242-500-3
SMILES :
C1CC(CCC1NCC2=CC(=CC(=C2N)Br)Br)O.Cl

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