alpha Tubulin Antibody (6A204): sc-69969

α Tubulin Antibody (6A204) is a mouse monoclonal IgG1 antibody that specifically recognizes α Tubulin across a wide range of species, including human, mouse, rat, and others. α Tubulin monoclonal antibody (6A204) is raised against Sarkosyl-resistant ribbons derived from Strongylocentrotus purpuratus (sea urchin) sperm axonemes, which ensures specificity for α Tubulin in microtubules. α Tubulin, along with β Tubulin, forms the core of microtubule structure, a critical component of the cytoskeleton. Microtubules play an essential role in maintaining cell shape, facilitating intracellular transport, and enabling cell division, particularly during mitotic spindle formation. α Tubulin is involved in microtubule filament nucleation at the centrosome, where stabilization and organization into dynamic structures occur for proper cell function. Structurally, α Tubulin is a globular protein that, when bound with β Tubulin, forms a heterodimer polymerizing to form hollow, cylindrical microtubules. α Tubulin undergoes several important post-translational modifications, including tyrosination and detyrosination, which regulate microtubule stability and interactions with motor proteins such as kinesins and dyneins, critical for cellular transport and motility. Precise regulation of α Tubulin′s structure and modifications is essential for processes like cell division, ciliary movement, and neuronal signaling. α Tubulin (6A204) antibody serves as a valuable tool for studying microtubule structure and dynamics, along with their involvement in cellular processes across various species.

The preferred alpha Tubulin antibody is alpha Tubulin Antibody (TU-02): sc-8035.