alpha-actinin-4 Antibody (LW-M23): sc-134236
- α-actinin-4 Antibody (LW-M23) is a mouse monoclonal IgG2a κ, cited in 9 publications, provided at 100 µg/ml
- raised against recombinant α-actinin-4 protein of human origin
- recommended for detection of α-actinin-4 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for α-actinin-4 Antibody (LW-M23). This work is in progress.
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α-actinin-4 Antibody (LW-M23) is a mouse monoclonal IgG2a antibody that detects α-actinin-4 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). α-actinin-4 is a crucial member of the spectrin gene family, which encodes a diverse group of cytoskeletal proteins, including spectrins, dystrophins, and α-actinins. α-actinin-4 is primarily located in the cytoskeleton of muscle and non-muscle cells, such as skeletal, cardiac, and smooth muscle cells, where α-actinin-4 plays a vital role in maintaining cellular structure and integrity. The unique structure of α-actinin-4, which includes one actin-binding domain, two calponin-homology domains, two EF-hand domains, and four spectrin repeats, allows α-actinin-4 to function effectively as a bundling protein that cross-links filamentous actin (F-actin), anchoring F-actin to various intracellular structures. This anchoring is essential for cellular processes such as muscle contraction and cell signaling. Defects in the gene encoding α-actinin-4 have been linked to focal segmental glomerulosclerosis 1 (FSGS1), a serious renal condition characterized by progressive kidney dysfunction and potential renal failure, highlighting α-actinin-4′s significance in both cellular function and human health.
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alpha-actinin-4 Antibody (LW-M23) References:
- Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells. | Quick, Q. and Skalli, O. 2010. Exp Cell Res. 316: 1137-47. PMID: 20156433
- Alpha-actinin 4 and tumorigenesis of breast cancer. | Hsu, KS. and Kao, HY. 2013. Vitam Horm. 93: 323-51. PMID: 23810014
- The fifth sense: Mechanosensory regulation of alpha-actinin-4 and its relevance for cancer metastasis. | Thomas, DG. and Robinson, DN. 2017. Semin Cell Dev Biol. 71: 68-74. PMID: 28579451
- α-Actinin-4 promotes metastasis in gastric cancer. | Liu, X. and Chu, KM. 2017. Lab Invest. 97: 1084-1094. PMID: 28581489
- Dynamin 2 interacts with α-actinin 4 to drive tumor cell invasion. | Burton, KM., et al. 2020. Mol Biol Cell. 31: 439-451. PMID: 31967944
- Localization of alpha-actinin-4 during infections by actin remodeling bacteria. | Dhanda, AS., et al. 2021. Anat Rec (Hoboken). 304: 1400-1419. PMID: 33099893
- α-Actinin 4 Links Vasopressin Short-Term and Long-Term Regulation of Aquaporin-2 in Kidney Collecting Duct Cells. | Ho, CH., et al. 2021. Front Physiol. 12: 725172. PMID: 34925053
- Alpha-actinin 4 and tumorigenesis of hepatocellular carcinoma. | Wang, G., et al. 2019. Transl Cancer Res. 8: 1374-1380. PMID: 35116880
- α-Actinin-4 recruits Shp2 into focal adhesions to potentiate ROCK2 activation in podocytes. | Tseng, CC., et al. 2022. Life Sci Alliance. 5: PMID: 36096674
- Antiproliferative Activity of Piceamycin by Regulating Alpha-Actinin-4 in Gemcitabine-Resistant Pancreatic Cancer Cells. | Lee, JH., et al. 2024. Biomol Ther (Seoul). 32: 123-135. PMID: 38148558
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-actinin-4 Antibody (LW-M23) | sc-134236 | 100 µg/ml | $339.00 |