Molecular structure of 11-deoxy-11-methylene-15-keto Prostaglandin D2, CAS Number: 958759-75-6
11-deoxy-11-methylene-15-keto Prostaglandin D2 (CAS 958759-75-6)
CAS Number:
958759-75-6
Molecular Weight:
348.5
Molecular Formula:
C21H32O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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One of the five primary enzymatic prostaglandins derived directly from PGH2. Many of the biological effects of PGD2 are transduced in vivo by a classical 7-transmembrane GPCR, the DP1 receptor.1 However, a second receptor, the chemokine-related CRTH2 receptor, also binds PGD2.2,3 This new receptor was recently identified on human eosinophils, where it binds selectively the PGD2 metabolite 13,14-dihydro-15-keto PGD2.4 Was prepared as a more chemically stable ligand for this receptor. There are no published studies of the pharmacological properties of 11-deoxy-11-methylene-15-keto PGD2.
11-deoxy-11-methylene-15-keto Prostaglandin D2 (CAS 958759-75-6) References
1 Boie, Y., Sawyer, N., Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor. J Biol Chem 270 18910-18916 (1995). 2 Gervais, F.G., Cruz, R., Chateauneuf, A., et al. Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP. J Allergy Clin Immunol 108(6) 982-988 (2002). 3 Monneret, G., Gravel, S., Diamond, M., et al. Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood 98(6) 1942-1948 (2001). 4 Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med 193(2) 255-261 (2001).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
11-deoxy-11-methylene-15-keto Prostaglandin D2, 100 µg | sc-220575 | 100 µg | $60.00 | |||
11-deoxy-11-methylene-15-keto Prostaglandin D2, 500 µg | sc-220575A | 500 µg | $270.00 |