Date published: 2025-10-29

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TMEM59 Ativadores

TMEM59," or "Transmembrane Protein 59," is a gene that encodes a protein belonging to the family of transmembrane proteins. As suggested by its name, TMEM59 is characterized by its location within the cellular membrane, indicating a role in cellular processes involving membrane dynamics.TMEM59 is involved in the regulation of endosomal trafficking, a critical process in the cellular transport and sorting of membrane-bound proteins and lipids. Endosomal trafficking is essential for various cellular functions, including signaling, nutrient uptake, and membrane protein recycling or degradation. TMEM59 contributes to the proper functioning of this system by influencing the movement and sorting of endosomal vesicles.

One of the key roles of TMEM59 is in the modulation of the Golgi apparatus, a central organelle in protein and lipid processing and trafficking. TMEM59 has been implicated in Golgi-to-endosome transport, influencing the sorting and delivery of proteins to their appropriate cellular destinations.Research has also highlighted the involvement of TMEM59 in neurodegenerative diseases, particularly in the context of Alzheimer's disease. TMEM59 may affect the processing and trafficking of amyloid precursor protein (APP), a key protein in the pathogenesis of Alzheimer's disease. Alterations in APP processing can lead to the accumulation of amyloid-beta, a hallmark of Alzheimer's pathology.Moreover, TMEM59's role in membrane trafficking and cell signaling pathways suggests its broader relevance in various physiological processes and potentially in other disease mechanisms.

VEJA TAMBÉM

Nome do ProdutoCAS #Numero de CatalogoQuantidadePrecoUso e aplicacaoNOTAS

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Um regulador da expressão genética, o ácido retinóico pode influenciar várias vias de sinalização, com potencial impacto no TMEM59.

Bafilomycin A1

88899-55-2sc-201550
sc-201550A
sc-201550B
sc-201550C
100 µg
1 mg
5 mg
10 mg
$96.00
$250.00
$750.00
$1428.00
280
(6)

Um inibidor da bomba de protões V-ATPase, que afecta a acidificação lisossomal e influencia potencialmente o papel do TMEM59 na triagem lisossomal.

Chloroquine

54-05-7sc-507304
250 mg
$68.00
2
(0)

Conhecida por afetar a função lisossomal, a cloroquina pode afetar indiretamente a atividade do TMEM59 relacionada com a triagem lisossomal.

Lithium

7439-93-2sc-252954
50 g
$214.00
(0)

Um inibidor da GSK-3, que afecta a sinalização Wnt e tem um impacto potencial na função do TMEM59.

FCM Lysing solution (1x)

sc-3621
150 ml
$61.00
8
(1)

Um agente lisossomotrópico que pode aumentar o pH lisossómico, influenciando potencialmente o papel do TMEM59 na função lisossómica.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Um inibidor do mTOR, que influencia a autofagia e a função lisossómica, com potencial impacto no TMEM59.

Tunicamycin

11089-65-9sc-3506A
sc-3506
5 mg
10 mg
$169.00
$299.00
66
(3)

Um inibidor da glicosilação ligada à N, que afecta o tráfico de proteínas e potencialmente a função do TMEM59.

Nocodazole

31430-18-9sc-3518B
sc-3518
sc-3518C
sc-3518A
5 mg
10 mg
25 mg
50 mg
$58.00
$83.00
$140.00
$242.00
38
(2)

Um agente despolimerizador de microtúbulos, que afecta o transporte intracelular, influenciando potencialmente o TMEM59.

IWP-2

686770-61-6sc-252928
sc-252928A
5 mg
25 mg
$94.00
$286.00
27
(1)

Um inibidor da produção de Wnt, o IWP-2 pode afetar indiretamente a função do TMEM59 nas vias de sinalização Wnt.