Date published: 2026-4-24

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PHK Inhibitors

Santa Cruz Biotechnology now offers a broad range of PHK Inhibitors for use in various applications. PHK Inhibitors are essential tools in the study of phosphorylase kinase (PHK), an enzyme that plays a pivotal role in the regulation of glycogen metabolism. By inhibiting PHK activity, researchers can explore the mechanisms through which PHK controls the phosphorylation and activation of glycogen phosphorylase, which is crucial for glycogen breakdown. These inhibitors are vital for dissecting the regulatory pathways involved in glycogenolysis and understanding how energy metabolism is managed in different cellular contexts. In scientific research, PHK Inhibitors are employed to investigate the signaling pathways that modulate glycogen metabolism. Researchers utilize these inhibitors to study the impact of PHK inhibition on glucose availability and energy production, providing insights into the broader aspects of metabolic control. Additionally, PHK Inhibitors are used in experiments to delineate the role of PHK in muscle and liver tissues, offering a deeper understanding of tissue-specific regulation of glycogen stores. These inhibitors also facilitate the study of metabolic diseases and conditions where glycogen metabolism is disrupted, enabling researchers to identify potential molecular targets for further investigation. The use of PHK Inhibitors supports the development of novel experimental models to probe the complex interactions between metabolic pathways and regulatory networks, advancing our knowledge of cellular energy homeostasis. View detailed information on our available PHK Inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

KT 5720

108068-98-0sc-3538
sc-3538A
sc-3538B
50 µg
100 µg
500 µg
$138.00
$220.00
$972.00
47
(2)

KT 5720, functioning as a potent PHK, uniquely interacts with protein kinases, particularly influencing the phosphorylation state of serine and threonine residues. Its structural conformation facilitates selective inhibition, altering kinase activity and downstream signaling pathways. The compound's kinetic properties allow for rapid binding and dissociation, enhancing its regulatory potential in cellular processes. Furthermore, its solubility in diverse solvents supports versatile interactions within complex biochemical systems.

Bisindolylmaleimide I (GF 109203X)

133052-90-1sc-24003A
sc-24003
1 mg
5 mg
$105.00
$242.00
36
(1)

Bisindolylmaleimide I (GF 109203X) acts as a selective protein kinase inhibitor, exhibiting a unique ability to stabilize the inactive conformation of kinases. This compound engages in specific hydrogen bonding and hydrophobic interactions, which modulate enzyme activity and influence cellular signaling cascades. Its distinct molecular architecture allows for targeted inhibition, while its favorable solubility profile enhances its compatibility with various biochemical environments, promoting effective engagement with multiple kinase targets.

K-252a

99533-80-9sc-200517
sc-200517B
sc-200517A
100 µg
500 µg
1 mg
$129.00
$214.00
$498.00
19
(2)

K-252a is a potent inhibitor of protein kinases, characterized by its ability to disrupt ATP binding through unique interactions with the enzyme's active site. This compound exhibits a distinctive binding affinity, facilitating conformational changes that hinder kinase activation. Its structural features promote specific van der Waals and electrostatic interactions, enhancing selectivity. Additionally, K-252a's solubility in diverse solvents allows for versatile applications in biochemical assays, making it a valuable tool for studying kinase dynamics.