IL-17REL Ativadores
IL-17REL is a member of the interleukin-17 (IL-17) family of cytokines, which are known for their role in inflammatory processes and host defense against infections. This family includes several members, such as IL-17A through IL-17F, each encoded by different genes and exhibiting distinct but related biological functions. IL-17 cytokines are predominantly produced by a unique subset of T cells known as Th17 cells, although other cell types like γδ T cells and innate immune cells can also produce them under certain conditions.
IL-17REL is the least characterized member of the IL-17 family and shares sequence homology with other IL-17 family cytokines, suggesting it may have similar biological activities. The "REL" suffix denotes its relationship to the other IL-17 family members, but also its distinctiveness, as it is not as extensively studied. Due to the naming conventions of cytokines, the "REL" might imply a relative or a homolog to the better-characterized IL-17 cytokines, particularly IL-17A and IL-17F, which are the most studied and are known to mediate pro-inflammatory responses.While the exact function of IL-17REL is not well-defined, it is presumed to be involved in immune system signaling pathways, contributing to the orchestration of immune responses. Like other IL-17 cytokines, it may play a role in inducing the production of other pro-inflammatory molecules, such as chemokines and cytokines, which recruit and activate other immune cells to the site of infection or inflammation.
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| Nome do Produto | CAS # | Numero de Catalogo | Quantidade | Preco | Uso e aplicacao | NOTAS |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
O PMA ativa a proteína quinase C, que pode levar à ativação do NF-κB, um fator de transcrição que pode aumentar a expressão de IL-17REL. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $96.00 $166.00 $459.00 $1615.00 | 12 | |
O LPS liga-se ao TLR4, iniciando uma cascata de sinalização que ativa o NF-κB, aumentando potencialmente a expressão de IL-17REL nas células imunitárias. | ||||||
R-848 | 144875-48-9 | sc-203231 sc-203231A sc-203231B sc-203231C | 5 mg 25 mg 100 mg 500 mg | $100.00 $300.00 $500.00 $1528.00 | 12 | |
O resiquimod ativa os TLR7 e TLR8, conduzindo à indução de citocinas pró-inflamatórias e podendo aumentar a regulação da IL-17REL. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $66.00 $278.00 | 6 | |
O imiquimod, um agonista do TLR7, pode estimular o sistema imunitário inato e pode induzir a expressão de IL-17REL. | ||||||
Dexamethasone Sodium Phosphate | 2392-39-4 | sc-204715 sc-204715A | 100 mg 500 mg | $54.00 $155.00 | 7 | |
Estes agonistas de TLR9 podem promover a ativação de NF-κB, conduzindo a um aumento da expressão de IL-17REL. | ||||||
Pam3Cys-Ser-(Lys)4, Hydrochloride | 112208-00-1 | sc-507471 | 2 mg | $550.00 | ||
Este agonista TLR1/2 pode desencadear uma cascata de sinalização que resulta na ativação do NF-κB e na potencial regulação positiva da IL-17REL. | ||||||
Polyinosinic-polycytidylic acid potassium salt | 31852-29-6 | sc-202767 | 5 mg | $194.00 | ||
Como agonista do TLR3, pode ativar o IRF3 e o NF-κB, possivelmente aumentando a expressão do IL-17REL. | ||||||