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ZWITTERGENT 3-16 Detergent (CAS 2281-11-0)

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Alternate Names:
Palmityl Sulfobetaine; 3-(N,N-Dimethylpalmitylammonio)propanesulfonate
Application:
ZWITTERGENT 3-16 Detergent is A zwitterionic detergent useful for solubilization of membrane proteins
CAS Number:
2281-11-0
Purity:
≥98%
Molecular Weight:
391.66
Molecular Formula:
C21H45NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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ZWITTERGENT 3-16 is a detergent that functions as a solubilizing agent in research and development applications. It acts by disrupting the hydrophobic interactions between molecules, allowing for the solubilization of hydrophobic compounds in aqueous solutions. This detergent′s mechanism of action involves the formation of micelles, which encapsulate the hydrophobic molecules, enabling their dispersion in the aqueous environment. ZWITTERGENT 3-16 achieves this by having both hydrophilic and hydrophobic regions in its molecular structure, allowing it to interact with both types of molecules. This detergent′s ability to solubilize hydrophobic compounds makes it a useful tool in various experimental contexts, where the solubilization of such compounds is necessary for further analysis or manipulation. Its mechanism of action at the molecular level involves the disruption of non-covalent interactions, facilitating the dispersion of hydrophobic molecules in aqueous solutions for research and development purposes.


ZWITTERGENT 3-16 Detergent (CAS 2281-11-0) References

  1. Rapid on-membrane proteolytic cleavage for Edman sequencing and mass spectrometric identification of proteins.  |  Pham, VC., et al. 2005. Electrophoresis. 26: 4243-51. PMID: 16240295
  2. Two-dimensional southwestern blotting and characterization of transcription factors on-blot.  |  Jiang, D., et al. 2009. J Proteome Res. 8: 3693-701. PMID: 19388704
  3. Recombinant expression, detergent solubilisation and purification of insect odorant receptor subunits.  |  Carraher, C., et al. 2013. Protein Expr Purif. 90: 160-9. PMID: 23770557
  4. Isolation and characterization of the alpha-galactosyl-1,4-beta-galactosyl-specific adhesin (P adhesin) from fimbriated Escherichia coli.  |  Hoschützky, H., et al. 1989. Infect Immun. 57: 76-81. PMID: 2562836
  5. Comparison of Different Buffers for Protein Extraction from Formalin-Fixed and Paraffin-Embedded Tissue Specimens.  |  Shen, K., et al. 2015. PLoS One. 10: e0142650. PMID: 26580073
  6. Purification and characterization of phospholamban from canine cardiac sarcoplasmic reticulum.  |  Inui, M., et al. 1985. J Biol Chem. 260: 3708-15. PMID: 3882714
  7. Identification and extraction of Pasteurella haemolytica membrane proteins.  |  Squire, PG., et al. 1984. Infect Immun. 45: 667-73. PMID: 6205995
  8. Detergent solubilization of cardiac 5'-nucleotidase.  |  Lutoslawska, G., et al. 1983. Experientia. 39: 507-8. PMID: 6303829
  9. Perturbation of the platelet plasma membrane is not sufficient for inhibition of thrombin-induced PKC-activity.  |  Mäkelä, JH. and Isomaa, B. 1993. Chem Biol Interact. 86: 187-98. PMID: 8485783
  10. Cell surface polysaccharide and protein antigens of an encapsulated Porphyromonas gingivalis 16-1 strain.  |  Ro, M., et al. 1995. Bull Tokyo Dent Coll. 36: 43-8. PMID: 8689741
  11. alpha-L-fucosyltransferases from radish primary roots.  |  Misawa, H., et al. 1996. Plant Physiol. 110: 665-73. PMID: 8742340
  12. Methodical analysis of protein-nitrocellulose interactions to design a refined digestion protocol.  |  Lui, M., et al. 1996. Anal Biochem. 241: 156-66. PMID: 8921181
  13. Examination of micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysis.  |  Erdjument-Bromage, H., et al. 1998. J Chromatogr A. 826: 167-81. PMID: 9871337

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

ZWITTERGENT 3-16 Detergent, 1 g

sc-281194A
1 g
$33.00

ZWITTERGENT 3-16 Detergent, 5 g

sc-281194
5 g
$63.00

ZWITTERGENT 3-16 Detergent, 25 g

sc-281194B
25 g
$176.00

ZWITTERGENT 3-16 Detergent, 100 g

sc-281194C
100 g
$634.00

ZWITTERGENT 3-16 Detergent, 250 g

sc-281194D
250 g
$1509.00

ZWITTERGENT 3-16 Detergent, 1 kg

sc-281194E
1 kg
$5056.00

ZWITTERGENT 3-16 DETERGENT (CAS 2281-11-0) What's the stability of Zwittergent 3-16 detergent, or expire date of sc-281194, Lot G2315?

Asked by: YueYue
Thank you for your question. Please contact our technical service directly so we can provide you with a COA with expiry date for this lot.
Answered by: Tech Support Europe
Date published: 2023-03-31

Hi I am looking for a zwittergent with an 18 carbon side chain, which would you recommend?

Asked by: Oonagh
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Tech Service 1
Date published: 2021-01-06

What is the CMC of this detergent, i.e., Zwittergent, 3-16 Detergent? What's the concentration recommend in ELISA or lateral flow assay?

Asked by: YDou
Thank you for your question. Unfortunately we do not have the CMC information. For both ELISA and Flow cytometry we suggest you do a titration to find optimal concentrations to use with your samples. You can find our recommended protocols here: https://www.scbt.com/scbt/resources/protocols
Answered by: Tech Service
Date published: 2019-04-17
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Rated 5 out of 5 by from Numerous publications cite the use of ZwittergentNumerous publications cite the use of Zwittergent 3-16 detergent in various chemistry applications. -SCBT Publication Review
Date published: 2015-02-13
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ZWITTERGENT 3-16 Detergent is rated 5.0 out of 5 by 1.
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