ZSCAN21 Antibody (3418F1a): sc-81142

ZSCAN21 Antibody (3418F1a) is a mouse monoclonal IgG2b antibody that detects ZSCAN21 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-ZSCAN21 antibody (3418F1a) is available as a non-conjugated format. ZSCAN21 protein, also known as ZNF38, Zipro1, or NY-REN-21, is a crucial member of the Krüppel C2H2-type zinc-finger family of transcriptional regulators, characterized by its SCAN domain at the N-terminus. ZSCAN21 plays a significant role in transcriptional regulation, particularly in proliferating cells, where ZSCAN21 is believed to be involved in gametogenesis in females and meiosis in males. The structure of ZSCAN21, which includes a Krüppel-type DNA-binding domain and a KRAB domain, is essential for function, as the KRAB domain interacts with KAP1, facilitating the recruitment of histone-modifying proteins that can alter chromatin structure and gene expression. By forming either homodimers or heterodimers with SCAND1, ZSCAN21 exhibits transcriptional activity vital for proper cellular function and development.

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ZSCAN21 Antibody (3418F1a) References:

1. BAC-mediated gene-dosage analysis reveals a role for Zipro1 (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin.  |  Yang, XW., et al. 1999. Nat Genet. 22: 327-35. PMID: 10431235
2. The ubiquitous transactivator Zfp-38 is upregulated during spermatogenesis with differential transcription.  |  Chowdhury, K., et al. 1992. Mech Dev. 39: 129-42. PMID: 1284028
3. Host cell targets of immediate-early protein BICP22 of bovine herpesvirus 1.  |  Saydam, O., et al. 2006. Vet Microbiol. 113: 185-92. PMID: 16352405
4. Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1.  |  Carneiro, FR., et al. 2006. Biochem Biophys Res Commun. 343: 260-8. PMID: 16540086
5. Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs.  |  O'Geen, H., et al. 2007. PLoS Genet. 3: e89. PMID: 17542650

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZSCAN21 Antibody (3418F1a) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ZSCAN21 Antibody (3418F1a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZSCAN21 Antibody (3418F1a) Specifications

Alternate Product Name: ZSCAN21

Product Clone Name: 3418F1a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: ZSCAN21

Epitope Species: human

Product Reactivity/Detection: ZSCAN21

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ZSCAN21 Antibody (3418F1a): N/A