ZP1 Antibody (M1.4): sc-32751
- ZP1 Antibody (M1.4) is a rat monoclonal IgG2a, cited in 2 publications, provided at 200 µg/ml
- raised against particulate murine zonae pellucidae
- recommended for detection of ZP1 of mouse origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ZP1 Antibody (M1.4). This work is in progress.
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ZP1 Antibody (M1.4) is a rat monoclonal IgG2a antibody that detects ZP1 in mouse samples through western blotting (WB) and immunoprecipitation (IP) applications. ZP1 is one of the three major glycoproteins that compose the mammalian zona pellucida, alongside ZP2 and ZP3, and plays a crucial role in the fertilization process. ZP1 is primarily located in the extracellular matrix surrounding the oocyte, where ZP1 forms a protective barrier essential for gamete interaction. The zona pellucida not only facilitates sperm binding to the oocyte but also ensures species-specific fertilization, preventing polyspermy. ZP1′s structural integrity is vital, as ZP1 contributes to the overall architecture of the zona pellucida, influencing sperm binding affinity and the subsequent acrosome reaction. Proper functioning of ZP1 is critical for successful fertilization, making ZP1 an important target for studies related to reproductive biology and fertility. Anti-ZP1 antibody (M1.4) is an invaluable tool for researchers investigating fertilization mechanisms and zona pellucida protein roles in reproductive health.
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ZP1 Antibody (M1.4) References:
- Abnormal zonae pellucidae in mice lacking ZP1 result in early embryonic loss. | Rankin, T., et al. 1999. Development. 126: 3847-55. PMID: 10433913
- Subcellular distribution of ZP1, ZP2, and ZP3 glycoproteins during folliculogenesis and demonstration of their topographical disposition within the zona matrix of mouse ovarian oocytes. | El-Mestrah, M., et al. 2002. Biol Reprod. 66: 866-76. PMID: 11906903
- Analysis of ZP1 gene reveals differences in zona pellucida composition in carnivores. | Moros-Nicolás, C., et al. 2018. Reprod Fertil Dev. 30: 272-285. PMID: 28679462
- Novel mutation in the ZP1 gene and clinical implications. | Yuan, P., et al. 2019. J Assist Reprod Genet. 36: 741-747. PMID: 30778819
- Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility. | Nishimura, K., et al. 2019. Nat Commun. 10: 3086. PMID: 31300655
- Homozygous Splice Site Mutation in ZP1 Causes Familial Oocyte Maturation Defect. | Okutman, Ö., et al. 2020. Genes (Basel). 11: PMID: 32244758
- Novel mutations in ZP1 and ZP2 cause primary infertility due to empty follicle syndrome and abnormal zona pellucida. | Luo, G., et al. 2020. J Assist Reprod Genet. 37: 2853-2860. PMID: 32829425
- A recurrent ZP1 variant is responsible for oocyte maturation defect with degenerated oocytes in infertile females. | Loeuillet, C., et al. 2022. Clin Genet. 102: 22-29. PMID: 35460069
- A Novel Homozygous Nonsense Mutation in ZP1 Causes Female Infertility due to Empty Follicle Syndrome. | Zou, T., et al. 2022. Reprod Sci. 29: 3516-3520. PMID: 35773450
- Mouse Zp1 encodes a zona pellucida protein homologous to egg envelope proteins in mammals and fish. | Epifano, O., et al. 1995. J Biol Chem. 270: 27254-8. PMID: 7592984
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZP1 Antibody (M1.4) | sc-32751 | 200 µg/ml | $322.00 |