Zonisamide-13C2-15N (CAS 1188265-58-8)

Zonisamide-13C2-15N is an anticonvulsant compound, sharing chemical similarities with acetazolamide. Found in the natural compound zonisamide from the Zuiki plant, this labeled variant contains two carbon atoms labeled with 13C and 15N, respectively. Such labeling facilitates differentiation from the non-labeled form, enabling researchers to track its in vivo metabolism. By monitoring the labeled compound within the body, researchers can gain valuable insights into its metabolic and excretory pathways. This information aids in drug design, side effect identification, and provides a basis for studying zonisamide′s pharmacokinetics and pharmacodynamics in diverse animal models. Zonisamide-13C2-15N operates via a mechanism of action akin to zonisamide itself. It functions as a sodium channel blocker, diminishing neuronal excitability and reducing seizure activity. Additionally, there is speculation that the compound may serve as a carbonic anhydrase inhibitor, thereby influencing brain pH regulation.