Zomepirac acyl-O-β-D-glucuronide (CAS 75871-31-7)
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Zomepirac acyl-O-β-D-glucuronide is a metabolite used extensively in chemical metabolism and pharmacokinetic research. It serves as a compound for understanding the glucuronidation process, a major pathway for the biotransformation of substances, which facilitates their excretion. In analytical studies, this glucuronide is utilized as a reference standard to validate and improve assays for detecting and quantifying the presence of zomepirac and its metabolites in biological fluids. Researchers use it to investigate the specificity and kinetics of the enzymes responsible for its formation, primarily the UDP-glucuronosyltransferases. Moreover, the study of this metabolite helps in elucidating the interactions between chemicals and the biochemical systems that process them, providing insights into the design of molecules with optimal metabolic profiles.
Zomepirac acyl-O-β-D-glucuronide (CAS 75871-31-7) References
- In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats. | Olsen, J., et al. 2005. Chem Res Toxicol. 18: 1729-36. PMID: 16300382
- Disposition of zomepirac sodium in man. | O'Neill, PJ., et al. 1982. J Clin Pharmacol. 22: 470-6. PMID: 7174855
- The utility of the bile-exteriorized rat as a source of reactive acyl glucuronides: studies with zomepirac. | King, AR. and Dickinson, RG. 1996. J Pharmacol Toxicol Methods. 36: 131-6. PMID: 8959578
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Zomepirac acyl-O-β-D-glucuronide, 2.5 mg | sc-476221 | 2.5 mg | $388.00 |