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Zolmitriptan-D6 (Major) (CAS 1217644-84-2)

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Alternate Names:
(4S)-4-[[3-[2-(Dimethyl-d6-amino)ethyl]-1H-indol-5-yl]methyl-2-oxazolidinone
Application:
Zolmitriptan-D6 (Major) is an agonist of SR-1B, SR-1D and SR-1
CAS Number:
1217644-84-2
Molecular Weight:
293.39
Molecular Formula:
C16H15D6N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Zolmitriptan-D6 (Major), a deuterated form of the compound zolmitriptan, is primarily used in research as an internal standard for mass spectrometric analyses. The incorporation of deuterium, a stable isotope of hydrogen, into the molecule does not alter the chemical structure significantly but provides a distinct mass difference that can be detected by mass spectrometry. This allows for precise quantification of zolmitriptan in mechanistic studies, as the deuterated analog co-elutes with the non-deuterated form during chromatographic separation, providing a reliable reference point. Researchers also utilize it in metabolic studies to trace the pathways and identify the metabolites of zolmitriptan, as the deuterated positions usually remain unchanged throughout the metabolic process. Additionally, Zolmitriptan-D6 (Major) finds application in the development of new analytical methods where accuracy and detection limits are critical.


Zolmitriptan-D6 (Major) (CAS 1217644-84-2) References

  1. A long-term study to maximise migraine relief with zolmitriptan.  |  Tepper, SJ., et al. 1999. Curr Med Res Opin. 15: 254-71. PMID: 10640258
  2. Bioequivalence study of 2 orodispersible formulations of zolmitriptan 5 mg in healthy volunteers.  |  Cánovas, M., et al. 2012. Arzneimittelforschung. 62: 482-6. PMID: 22918855
  3. Pharmacokinetics and Skin Tolerability of Intracutaneous Zolmitriptan Delivery in Swine Using Adhesive Dermally Applied Microarray.  |  Nguyen, J., et al. 2018. J Pharm Sci. 107: 2192-2197. PMID: 29772224
  4. Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding.  |  Amundsen, S., et al. 2021. Basic Clin Pharmacol Toxicol. 128: 795-804. PMID: 33730376
  5. Computer-aided design and synthesis of 5-substituted tryptamines and their pharmacology at the 5-HT1D receptor: discovery of compounds with potential anti-migraine properties.  |  Glen, RC., et al. 1995. J Med Chem. 38: 3566-80. PMID: 7658443
  6. The tolerability and pharmacokinetics of the novel antimigraine compound 311C90 in healthy male volunteers.  |  Seaber, E., et al. 1996. Br J Clin Pharmacol. 41: 141-7. PMID: 8838441

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Zolmitriptan-D6 (Major), 1 mg

sc-220416
1 mg
$490.00